Electrical conductivity and permittivity of murine myocardium

Karthik Raghavan, John E. Porterfield, Anil T.G. Kottam, Marc D. Feldman, Daniel Escobedo, Jonathan W. Valvano, John A. Pearce

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A classic problem in traditional conductance measurement of left ventricular (LV) volume is the separation of the contributions of myocardium from blood. Measurement of both the magnitude and the phase of admittance allow estimation of the time-varying myocardial contribution, which provides a substantial improvement by eliminating the need for hypertonic saline injection. We present in vivo epicardial surface probe measurements of electrical properties in murine myocardium using two different techniques (a digital and an analog approach). These methods exploit the capacitive properties of the myocardium, and both methods yield similar results. The relative permittivity varies from approximately 100 000 at 2 kHz to approximately 5000 at 50 kHz. The electrical conductivity is approximately constant at 0.16 S/m over the same frequency range. These values can be used to estimate and eliminate the time-varying myocardial contribution from the combined signal obtained in LV conductance catheter measurements, thus yielding the blood contribution alone. To study the effects of albumin on the blood conductivity, we also present electrical conductivity estimates of murine blood with and without typical administrations of albumin during the experiment. The blood conductivity is significantly altered (p < 0.0001) by administering albumin (0.941 S/m with albumin, 0.478 S/m without albumin).

Original languageEnglish (US)
Pages (from-to)2044-2053
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Issue number8
StatePublished - Aug 2009


  • Admittance
  • Blood conductivity
  • Conductance
  • Myocardial conductivity
  • Myocardial permittivity

ASJC Scopus subject areas

  • Biomedical Engineering


Dive into the research topics of 'Electrical conductivity and permittivity of murine myocardium'. Together they form a unique fingerprint.

Cite this