Efficient Synthesis of Pyrazoles by pH Dependent Isomerization of Enaminodiones

Jie Lei; Yong Ding; Dian Yong Tang; Hong yu Li; Zhi Gang Xu; Zhong Zhu Chen

doi:10.1002/ajoc.202200448

Efficient Synthesis of Pyrazoles by pH Dependent Isomerization of Enaminodiones

Jie Lei, Yong Ding, Dian Yong Tang, Hong yu Li, Zhi Gang Xu, Zhong Zhu Chen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A chromone-based Michael reaction using water as solvent and nucleophile was firstly developed to derivatize chromone via a multicomponent reaction (MCR) cascade sequence in absence of metal catalyst. A series of versatile enaminodiones was synthesized and further successfully transferred into two different pyrazoles with the same starting material under facile and mild condition by a pH control of the preferred isomer.

Original language	English (US)
Article number	e202200448
Journal	Asian Journal of Organic Chemistry
Volume	12
Issue number	2
DOIs	https://doi.org/10.1002/ajoc.202200448
State	Published - Feb 2023
Externally published	Yes

Keywords

Chromone
Michael addition
Pyrazole
Water
pH Dependent

ASJC Scopus subject areas

Organic Chemistry

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10.1002/ajoc.202200448

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title = "Efficient Synthesis of Pyrazoles by pH Dependent Isomerization of Enaminodiones",

abstract = "A chromone-based Michael reaction using water as solvent and nucleophile was firstly developed to derivatize chromone via a multicomponent reaction (MCR) cascade sequence in absence of metal catalyst. A series of versatile enaminodiones was synthesized and further successfully transferred into two different pyrazoles with the same starting material under facile and mild condition by a pH control of the preferred isomer.",

keywords = "Chromone, Michael addition, Pyrazole, Water, pH Dependent",

author = "Jie Lei and Yong Ding and Tang, {Dian Yong} and Li, {Hong yu} and Xu, {Zhi Gang} and Chen, {Zhong Zhu}",

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doi = "10.1002/ajoc.202200448",

language = "English (US)",

volume = "12",

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AU - Lei, Jie

AU - Ding, Yong

AU - Tang, Dian Yong

AU - Li, Hong yu

AU - Xu, Zhi Gang

AU - Chen, Zhong Zhu

PY - 2023/2

Y1 - 2023/2

N2 - A chromone-based Michael reaction using water as solvent and nucleophile was firstly developed to derivatize chromone via a multicomponent reaction (MCR) cascade sequence in absence of metal catalyst. A series of versatile enaminodiones was synthesized and further successfully transferred into two different pyrazoles with the same starting material under facile and mild condition by a pH control of the preferred isomer.

AB - A chromone-based Michael reaction using water as solvent and nucleophile was firstly developed to derivatize chromone via a multicomponent reaction (MCR) cascade sequence in absence of metal catalyst. A series of versatile enaminodiones was synthesized and further successfully transferred into two different pyrazoles with the same starting material under facile and mild condition by a pH control of the preferred isomer.

KW - Chromone

KW - Michael addition

KW - Pyrazole

KW - Water

KW - pH Dependent

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JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

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Efficient Synthesis of Pyrazoles by pH Dependent Isomerization of Enaminodiones

Abstract

Keywords

ASJC Scopus subject areas

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