Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis

W. R. Kirkpatrick; R. K. McAtee; A. W. Fothergill; M. G. Rinaldi; T. F. Patterson

doi:10.1128/AAC.44.10.2865-2868.2000

Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis

W. R. Kirkpatrick
, R. K. McAtee
, A. W. Fothergill
, M. G. Rinaldi
, T. F. Patterson

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericln B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.

Original language	English (US)
Pages (from-to)	2865-2868
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	44
Issue number	10
DOIs	https://doi.org/10.1128/AAC.44.10.2865-2868.2000
State	Published - 2000

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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10.1128/AAC.44.10.2865-2868.2000

Cite this

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abstract = "Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericln B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.",

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AU - Fothergill, A. W.

AU - Rinaldi, M. G.

AU - Patterson, T. F.

PY - 2000

Y1 - 2000

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AB - Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericln B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.

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U2 - 10.1128/AAC.44.10.2865-2868.2000

DO - 10.1128/AAC.44.10.2865-2868.2000

M3 - Article

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AN - SCOPUS:0033797988

SN - 0066-4804

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JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

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ER -

Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis

Abstract

ASJC Scopus subject areas

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