Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis

W. R. Kirkpatrick; R. K. McAtee; A. W. Fothergill; M. G. Rinaldi; T. F. Patterson

doi:10.1128/AAC.44.10.2865-2868.2000

Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis

W. R. Kirkpatrick, R. K. McAtee, A. W. Fothergill, M. G. Rinaldi, T. F. Patterson

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericln B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.

Original language	English (US)
Pages (from-to)	2865-2868
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	44
Issue number	10
DOIs	https://doi.org/10.1128/AAC.44.10.2865-2868.2000
State	Published - 2000

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

Access to Document

10.1128/AAC.44.10.2865-2868.2000

Cite this

@article{7c398b56816e4a76be3087501a6185f7,

title = "Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis",

abstract = "Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericln B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.",

author = "Kirkpatrick, {W. R.} and McAtee, {R. K.} and Fothergill, {A. W.} and Rinaldi, {M. G.} and Patterson, {T. F.}",

year = "2000",

doi = "10.1128/AAC.44.10.2865-2868.2000",

language = "English (US)",

volume = "44",

pages = "2865--2868",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "10",

}

TY - JOUR

T1 - Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis

AU - Kirkpatrick, W. R.

AU - McAtee, R. K.

AU - Fothergill, A. W.

AU - Rinaldi, M. G.

AU - Patterson, T. F.

PY - 2000

Y1 - 2000

N2 - Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericln B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.

AB - Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericln B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.

UR - http://www.scopus.com/inward/record.url?scp=0033797988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033797988&partnerID=8YFLogxK

U2 - 10.1128/AAC.44.10.2865-2868.2000

DO - 10.1128/AAC.44.10.2865-2868.2000

M3 - Article

C2 - 10991875

AN - SCOPUS:0033797988

SN - 0066-4804

VL - 44

SP - 2865

EP - 2868

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 10

ER -

Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this