Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis

W. R. Kirkpatrick, R. K. McAtee, A. W. Fothergill, M. G. Rinaldi, T. F. Patterson

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericln B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.

Original languageEnglish (US)
Pages (from-to)2865-2868
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume44
Issue number10
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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