Efficacy of sedation of children with chloral hydrate

Cpt Peter D. Rumm, Col Richard T. Takao, Maj Donald J. Fox, Ltc Sidney W. Atkinson

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Chloral hydrate has been used extensively to sedate children, but at Brooke Army Medical Center, other drug combinations were becoming increasingly popular due to a perception that chloral hydrate had a high rate of failure, especially with younger or neurologically impaired children. Therefore, 50 children were given the drug before a diagnostic study, and patient data and a sedation score were recorded on a worksheet. Of 50 children, 43 (86%) were “successfully sedated” on the first attempt with no side effects. Children with neurologic disorders had a much greater (27% vs 4%) failure rate than “normal” children. The sedation rate did not significantly differ by age, sex, or initial drug dosage. The study suggest that chloral hydrate is a safe and effective oral sedative but that children with neurologic disorders may need alternative drugs for sedation.

Original languageEnglish (US)
Pages (from-to)1040-1043
Number of pages4
JournalSouthern medical journal
Issue number9
StatePublished - Sep 1990
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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