Efficacy of SCH56592 in a rabbit model of invasive aspergillosis

William R. Kirkpatrick, Robert K. McAtee, Annette W. Fothergill, David Loebenberg, Michael G. Rinaldi, Thomas F. Patterson

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.

Original languageEnglish (US)
Pages (from-to)780-782
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume44
Issue number3
DOIs
StatePublished - Mar 2000

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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