Efficacy of SCH56592 in a rabbit model of invasive aspergillosis

William R. Kirkpatrick, Robert K. McAtee, Annette W. Fothergill, David Loebenberg, Michael G. Rinaldi, Thomas F. Patterson

Research output: Contribution to journalArticle

54 Scopus citations


SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.

Original languageEnglish (US)
Pages (from-to)780-782
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number3
StatePublished - Mar 1 2000


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Kirkpatrick, W. R., McAtee, R. K., Fothergill, A. W., Loebenberg, D., Rinaldi, M. G., & Patterson, T. F. (2000). Efficacy of SCH56592 in a rabbit model of invasive aspergillosis. Antimicrobial agents and chemotherapy, 44(3), 780-782. https://doi.org/10.1128/AAC.44.3.780-782.2000