TY - JOUR
T1 - Efficacy of SCH56592 in a rabbit model of invasive aspergillosis
AU - Kirkpatrick, William R.
AU - McAtee, Robert K.
AU - Bodi, Annette M
AU - Loebenberg, David
AU - Rinaldi, Michael G.
AU - Patterson, Thomas F.
PY - 2000/3
Y1 - 2000/3
N2 - SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.
AB - SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033998525&partnerID=8YFLogxK
U2 - 10.1128/AAC.44.3.780-782.2000
DO - 10.1128/AAC.44.3.780-782.2000
M3 - Article
C2 - 10681359
AN - SCOPUS:0033998525
SN - 0066-4804
VL - 44
SP - 780
EP - 782
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 3
ER -