Efficacy of SCH56592 in a rabbit model of invasive aspergillosis

William R. Kirkpatrick, Robert K. McAtee, Annette W. Fothergill, David Loebenberg, Michael G. Rinaldi, Thomas F Patterson

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.

Original languageEnglish (US)
Pages (from-to)780-782
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume44
Issue number3
DOIs
StatePublished - Mar 2000

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Aspergillosis
Rabbits
Itraconazole
Amphotericin B
Aspergillus
Mortality

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Kirkpatrick, W. R., McAtee, R. K., Fothergill, A. W., Loebenberg, D., Rinaldi, M. G., & Patterson, T. F. (2000). Efficacy of SCH56592 in a rabbit model of invasive aspergillosis. Antimicrobial Agents and Chemotherapy, 44(3), 780-782. https://doi.org/10.1128/AAC.44.3.780-782.2000

Efficacy of SCH56592 in a rabbit model of invasive aspergillosis. / Kirkpatrick, William R.; McAtee, Robert K.; Fothergill, Annette W.; Loebenberg, David; Rinaldi, Michael G.; Patterson, Thomas F.

In: Antimicrobial Agents and Chemotherapy, Vol. 44, No. 3, 03.2000, p. 780-782.

Research output: Contribution to journalArticle

Kirkpatrick, WR, McAtee, RK, Fothergill, AW, Loebenberg, D, Rinaldi, MG & Patterson, TF 2000, 'Efficacy of SCH56592 in a rabbit model of invasive aspergillosis', Antimicrobial Agents and Chemotherapy, vol. 44, no. 3, pp. 780-782. https://doi.org/10.1128/AAC.44.3.780-782.2000
Kirkpatrick, William R. ; McAtee, Robert K. ; Fothergill, Annette W. ; Loebenberg, David ; Rinaldi, Michael G. ; Patterson, Thomas F. / Efficacy of SCH56592 in a rabbit model of invasive aspergillosis. In: Antimicrobial Agents and Chemotherapy. 2000 ; Vol. 44, No. 3. pp. 780-782.
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