Efficacy of SCH56592 in a rabbit model of invasive aspergillosis

William R. Kirkpatrick, Robert K. McAtee, Annette W. Fothergill, David Loebenberg, Michael G. Rinaldi, Thomas F. Patterson

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Abstract

SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.

Original languageEnglish (US)
Pages (from-to)780-782
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume44
Issue number3
DOIs
StatePublished - Mar 1 2000

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Kirkpatrick, W. R., McAtee, R. K., Fothergill, A. W., Loebenberg, D., Rinaldi, M. G., & Patterson, T. F. (2000). Efficacy of SCH56592 in a rabbit model of invasive aspergillosis. Antimicrobial agents and chemotherapy, 44(3), 780-782. https://doi.org/10.1128/AAC.44.3.780-782.2000