Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2)

R. A. Otten, D. K. Smith, D. R. Adams, J. K. Pullium, E. Jackson, C. N. Kim, H. Jaffe, R. Janssen, S. Butera, T. M. Folks

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Postexposure prophylaxis (PEP) after intravaginal exposure to human immunodeficiency virus (HIV) was investigated using the HIV type 2 (HIV-2)/pig-tailed macaque transmission model. PEP for 28 days with the reverse transcriptase inhibitor (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA; tenofovir) was initiated 12 to 72 h following HIV-2 exposure. Systemic infection was not evident in the 12- and 36-h groups, as defined by plasma viremia, cell-associated provirus, antibody responses, and lymph node virus. Breakthrough infection in the 72-h group was detected at week 16 post-virus exposure. These results demonstrate for the first time using a vaginal transmission model that early intervention after high-risk sexual exposures may prevent infection.

Original languageEnglish (US)
Pages (from-to)9771-9775
Number of pages5
JournalJournal of Virology
Volume74
Issue number20
DOIs
StatePublished - 2000
Externally publishedYes

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Retroviridae
Tenofovir
Human immunodeficiency virus 2
Macaca nemestrina
HIV-2
Macaca
disease control
Swine
Infection
infection
Viruses
proviruses
Proviruses
viruses
Reverse Transcriptase Inhibitors
RNA-directed DNA polymerase
Viremia
viremia
Human immunodeficiency virus
adenine

ASJC Scopus subject areas

  • Immunology

Cite this

Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2). / Otten, R. A.; Smith, D. K.; Adams, D. R.; Pullium, J. K.; Jackson, E.; Kim, C. N.; Jaffe, H.; Janssen, R.; Butera, S.; Folks, T. M.

In: Journal of Virology, Vol. 74, No. 20, 2000, p. 9771-9775.

Research output: Contribution to journalArticle

Otten, RA, Smith, DK, Adams, DR, Pullium, JK, Jackson, E, Kim, CN, Jaffe, H, Janssen, R, Butera, S & Folks, TM 2000, 'Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2)', Journal of Virology, vol. 74, no. 20, pp. 9771-9775. https://doi.org/10.1128/JVI.74.20.9771-9775.2000
Otten, R. A. ; Smith, D. K. ; Adams, D. R. ; Pullium, J. K. ; Jackson, E. ; Kim, C. N. ; Jaffe, H. ; Janssen, R. ; Butera, S. ; Folks, T. M. / Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2). In: Journal of Virology. 2000 ; Vol. 74, No. 20. pp. 9771-9775.
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