TY - JOUR
T1 - Efficacy of fluconazole in experimental invasive aspergillosis
AU - Patterson, Thomas F.
AU - Miniter, Peggy
AU - Andriole, Vincent T.
N1 - Funding Information:
This research was supported by a Hull Cancer Research Award from the New Haven Foundation and YaleComprehensive Cancer Center and by a grant from Pfizer Central Research. Dr. Patterson is a Daland Fellow of the American Philosophical Society and is a recipient of a National Foundation for Infectious Diseases/Janssen Pharmaceutica Fellowship for Medical Mycology.
PY - 1990/3
Y1 - 1990/3
N2 - The efficacy of fluconazole against Aspergillus fumigatus was evaluated in an immunosuppressed, temporarily leukopenic rabbit model of invasive aspergillosis. Fluconazole was given at a dosage of 60 mg/kg twice daily and was compared with amphotericin B given intravenously at a dosage of 1.5 mg/(kg.d). Fluconazole reduced the tissue burden of Aspergillus from that in untreated controls by 10- to 1OO-fold in liver, kidney, and lung. However, at these doses amphotericin B was more effective in sterilizing tissues and in reducing the tissue burden of Aspergillus in those organs. Both fluconazole and amphotericin B decreased or eliminated circulating Aspergillus antigen and improved survival over that of untreated controls. Thus fluconazole shows activity in this rabbit model of invasive aspergillosis and should be further evaluated for use in the treatment of this disease.
AB - The efficacy of fluconazole against Aspergillus fumigatus was evaluated in an immunosuppressed, temporarily leukopenic rabbit model of invasive aspergillosis. Fluconazole was given at a dosage of 60 mg/kg twice daily and was compared with amphotericin B given intravenously at a dosage of 1.5 mg/(kg.d). Fluconazole reduced the tissue burden of Aspergillus from that in untreated controls by 10- to 1OO-fold in liver, kidney, and lung. However, at these doses amphotericin B was more effective in sterilizing tissues and in reducing the tissue burden of Aspergillus in those organs. Both fluconazole and amphotericin B decreased or eliminated circulating Aspergillus antigen and improved survival over that of untreated controls. Thus fluconazole shows activity in this rabbit model of invasive aspergillosis and should be further evaluated for use in the treatment of this disease.
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U2 - 10.1093/clinids/12.Supplement_3.S281
DO - 10.1093/clinids/12.Supplement_3.S281
M3 - Article
C2 - 2184506
AN - SCOPUS:0025230469
SN - 0162-0886
VL - 12
SP - S281-S285
JO - Reviews of Infectious Diseases
JF - Reviews of Infectious Diseases
ER -