Efficacy of echinocandins against murine infections by Diutina (Candida) rugosa

Marta Sanchis, Deanna A. Sutton, Nathan Wiederhold, Josep Guarro, Javier Capilla

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Echinocandins are recommended as a first-line therapy for invasive candidiasis. Candida rugosa was recently transferred to the new genus Diutina. We have determined the in vitro killing kinetics of two echinocandins, anidulafungin, and caspofungin and their in vivo efficacy, administering doses of 5 or 10 mg/kg, and 1 or 5 mg/kg, respectively against 2 clinical strains of D. rugosa. Both drugs showed a fungicidal concentration-dependent activity and, in a neutropenic murine model of disseminated infection, were able to reduce tissue burden and to prolong survival of mice. These results suggest that both echinocandins could be useful to treat infections by this fungus when isolates show minimal inhibitory concentrations within the range of susceptibility for both drugs.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume86
Issue number1
DOIs
StatePublished - Sep 1 2016

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Keywords

  • Anidulafungin
  • Animal model
  • Antifungals
  • Caspofungin
  • Diutina rugosa
  • Fungal infections

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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