Efficacy of echinocandins against murine infections by Diutina (Candida) rugosa

Marta Sanchis; Deanna A. Sutton; Nathan P. Wiederhold; Josep Guarro; Javier Capilla

doi:10.1016/j.diagmicrobio.2016.05.014

Efficacy of echinocandins against murine infections by Diutina (Candida) rugosa

Marta Sanchis, Deanna A. Sutton, Nathan P. Wiederhold, Josep Guarro, Javier Capilla

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Echinocandins are recommended as a first-line therapy for invasive candidiasis. Candida rugosa was recently transferred to the new genus Diutina. We have determined the in vitro killing kinetics of two echinocandins, anidulafungin, and caspofungin and their in vivo efficacy, administering doses of 5 or 10 mg/kg, and 1 or 5 mg/kg, respectively against 2 clinical strains of D. rugosa. Both drugs showed a fungicidal concentration-dependent activity and, in a neutropenic murine model of disseminated infection, were able to reduce tissue burden and to prolong survival of mice. These results suggest that both echinocandins could be useful to treat infections by this fungus when isolates show minimal inhibitory concentrations within the range of susceptibility for both drugs.

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	Diagnostic Microbiology and Infectious Disease
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/j.diagmicrobio.2016.05.014
State	Published - Sep 1 2016

Keywords

Anidulafungin
Animal model
Antifungals
Caspofungin
Diutina rugosa
Fungal infections

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.diagmicrobio.2016.05.014

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title = "Efficacy of echinocandins against murine infections by Diutina (Candida) rugosa",

abstract = "Echinocandins are recommended as a first-line therapy for invasive candidiasis. Candida rugosa was recently transferred to the new genus Diutina. We have determined the in vitro killing kinetics of two echinocandins, anidulafungin, and caspofungin and their in vivo efficacy, administering doses of 5 or 10 mg/kg, and 1 or 5 mg/kg, respectively against 2 clinical strains of D. rugosa. Both drugs showed a fungicidal concentration-dependent activity and, in a neutropenic murine model of disseminated infection, were able to reduce tissue burden and to prolong survival of mice. These results suggest that both echinocandins could be useful to treat infections by this fungus when isolates show minimal inhibitory concentrations within the range of susceptibility for both drugs.",

keywords = "Anidulafungin, Animal model, Antifungals, Caspofungin, Diutina rugosa, Fungal infections",

author = "Marta Sanchis and Sutton, {Deanna A.} and Wiederhold, {Nathan P.} and Josep Guarro and Javier Capilla",

note = "Funding Information: This project has been partially funded by the European Union{\textquoteright}s Seventh Framework Programme for research, technological development and demonstration under grant agreement no. HEALTH-2013-INNOVATION-2-601963. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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doi = "10.1016/j.diagmicrobio.2016.05.014",

language = "English (US)",

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AU - Sanchis, Marta

AU - Sutton, Deanna A.

AU - Wiederhold, Nathan P.

AU - Guarro, Josep

AU - Capilla, Javier

N1 - Funding Information: This project has been partially funded by the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no. HEALTH-2013-INNOVATION-2-601963. Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/9/1

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N2 - Echinocandins are recommended as a first-line therapy for invasive candidiasis. Candida rugosa was recently transferred to the new genus Diutina. We have determined the in vitro killing kinetics of two echinocandins, anidulafungin, and caspofungin and their in vivo efficacy, administering doses of 5 or 10 mg/kg, and 1 or 5 mg/kg, respectively against 2 clinical strains of D. rugosa. Both drugs showed a fungicidal concentration-dependent activity and, in a neutropenic murine model of disseminated infection, were able to reduce tissue burden and to prolong survival of mice. These results suggest that both echinocandins could be useful to treat infections by this fungus when isolates show minimal inhibitory concentrations within the range of susceptibility for both drugs.

AB - Echinocandins are recommended as a first-line therapy for invasive candidiasis. Candida rugosa was recently transferred to the new genus Diutina. We have determined the in vitro killing kinetics of two echinocandins, anidulafungin, and caspofungin and their in vivo efficacy, administering doses of 5 or 10 mg/kg, and 1 or 5 mg/kg, respectively against 2 clinical strains of D. rugosa. Both drugs showed a fungicidal concentration-dependent activity and, in a neutropenic murine model of disseminated infection, were able to reduce tissue burden and to prolong survival of mice. These results suggest that both echinocandins could be useful to treat infections by this fungus when isolates show minimal inhibitory concentrations within the range of susceptibility for both drugs.

KW - Anidulafungin

KW - Animal model

KW - Antifungals

KW - Caspofungin

KW - Diutina rugosa

KW - Fungal infections

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Efficacy of echinocandins against murine infections by Diutina (Candida) rugosa

Abstract

Keywords

ASJC Scopus subject areas

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