Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: A randomized, double-blind, placebo-controlled study

Ralph A. Defronzo, Penny R. Fleck, Craig A. Wilson, Qais Mekki

Research output: Contribution to journalArticle

179 Scopus citations

Abstract

OBJECTIVE - To evaluate the dipeptidyl peptidase-4 (DPP-4) inhibitor alogliptin in drug- naive patients with inadequately controlled type 2 diabetes. RESEARCH DESIGN AND METHODS - This double-blind, placebo-controlled, multicenter study included 329 patients with poorly controlled diabetes randomized to once-daily treatment with 12.5 mg alogliptin (n = 133), 25 mg alogliptin (n = 131), or placebo (n = 65) for 26 weeks. Primary efficacy end point was mean change from baseline in A1C at the final visit. RESULTS - At week 26, mean change in A1C was significantly greater (P < 0.001) for 12.5 mg (-0.56%) and 25 mg (-0.59%) alogliptin than placebo ( - 0.02%). Reductions in fasting plasma glucose were also greater (P < 0.001) in alogliptin-treated patients than in those receiving placebo. Overall, incidences of adverse events (67.4-70.3%) and hypoglycemia (1.5-3.0%) were similar across treatment groups. CONCLUSIONS - Alogliptin monotherapy was well tolerated and significantly improved glycemic control in patients with type 2 diabetes, without raising the incidence of hypoglycemia.

Original languageEnglish (US)
Pages (from-to)2315-2317
Number of pages3
JournalDiabetes care
Volume31
Issue number12
DOIs
Publication statusPublished - Dec 1 2008

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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