TY - JOUR
T1 - Effects on peroxides on rodent skin
T2 - Epidermal hyperplasia and tumor promotion
AU - Klein-Szanto, A. J.P.
AU - Slaga, T. J.
N1 - Funding Information:
Manuscript received September 9, 1981; accepted for publication December 29, 1981. . Research sponsored by NIH Grants CA 21104 and CA 29540 and the Office of Health and Environmental Research, U.S. Department of Energy, under contract W-7405-eng-26 with the Union Carbide Corporation. Reprint requests to: Dr. Klein-Szanto, Biology Division, Oak Ridge National Laboratory, P.O. Box Y, Oak Ridge, TN 37830. Abbreviations: BP: benzoyl peroxide DMBA: dimethyl benzanthracene LP: lauroyl peroxide
PY - 1982
Y1 - 1982
N2 - Free radical generating peroxides are potent skin irritants. After a single topical application of either 10, 20, or 40 mg of lauroyl peroxide or benzoyl peroxide on the dorsal skin of Sencar mice, the epidermal thickness increased markedly. No major inflammatory or vascular alterations were noted. On the other hand, 15 or 30% hydrogen peroxide produced an extensive epidermolysis, as well as inflammation and vascular injury, followed by quick regeneration and epidermal hyperplasia. Both lauroyl peroxide- and benzoyl peroxide-induced hyperplasias were characterized by a sustained production of dark basal keratinocytes, which constituted approximately 10% of the basal cell population during the first week after single topical application. Hydrogen peroxide-induced epidermal hyperplasias also exhibited numerous dark cells, but their presence was less sustained. Although all these peroxides were inactive either as initiators or as complete carcinogens, lauroyl peroxide was as effective as benzoyl peroxide when used as a skin tumor promoter in a two-stage carcinogenesis protocol. In a similar experimental protocol, hydrogen peroxide proved to be a very weak skin tumor promoter.
AB - Free radical generating peroxides are potent skin irritants. After a single topical application of either 10, 20, or 40 mg of lauroyl peroxide or benzoyl peroxide on the dorsal skin of Sencar mice, the epidermal thickness increased markedly. No major inflammatory or vascular alterations were noted. On the other hand, 15 or 30% hydrogen peroxide produced an extensive epidermolysis, as well as inflammation and vascular injury, followed by quick regeneration and epidermal hyperplasia. Both lauroyl peroxide- and benzoyl peroxide-induced hyperplasias were characterized by a sustained production of dark basal keratinocytes, which constituted approximately 10% of the basal cell population during the first week after single topical application. Hydrogen peroxide-induced epidermal hyperplasias also exhibited numerous dark cells, but their presence was less sustained. Although all these peroxides were inactive either as initiators or as complete carcinogens, lauroyl peroxide was as effective as benzoyl peroxide when used as a skin tumor promoter in a two-stage carcinogenesis protocol. In a similar experimental protocol, hydrogen peroxide proved to be a very weak skin tumor promoter.
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U2 - 10.1111/1523-1747.ep12510444
DO - 10.1111/1523-1747.ep12510444
M3 - Article
C2 - 7086173
AN - SCOPUS:0019995464
VL - 79
SP - 30
EP - 34
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 1
ER -