Abstract
Activation of alpha-1 adrenoceptors, via systemic injection of agonists such as cirazoline and phenylpropanolamine (PPA), reliably suppresses food intake in rats. These effects are thought to result from stimulation of central α1-adrenoceptors within the rat paraventricular hypothalamic nucleus (PVN), based on studies in which direct injections of cirazoline, methoxamine, phenylephrine and PPA into PVN suppress food intake. Because relatively few α1-agonists have been tested to date using the systemic route of exposure, the preent study examined the effects of the α1-adrenoceptor agonists amidephrine and SKF-89748 on food and water intake. Adult male rats received systemic injections (IP) of either amidephrine (0.025, 0.05, 0.01 mg/kg) or of SK&F 89748 (0.01, 0.02, and 0.04 mg/kg). Amidephrine markedly suppressed food intake (ED50=0.49 mg/kg) and water intake (ED50=0.50 mg/kg), while SK&F 89748 marginally suppressed food intake (ED50=0.37 mg/kg) and was less potent in suppressing water intake (ED50=0.76 mg/kg). These results document that systemic injection of the α1-adrenoceptor agonists amidephrine and SK&F 89748 induces anorexia with amidephrine exerting greater potency than SK&F 89748. These results further support the hypothesis that stimulation of α1-adrenoceptors suppresses food intake.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-174 |
| Number of pages | 6 |
| Journal | Life Sciences |
| Volume | 53 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Effects on food and water intake of the α1-adrenoceptor agonists amidephrine and SK&F-89748. / Morien, Annie; McMahon, Lance; Wellman, Paul J.
In: Life Sciences, Vol. 53, No. 2, 1993, p. 169-174.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects on food and water intake of the α1-adrenoceptor agonists amidephrine and SK&F-89748
AU - Morien, Annie
AU - McMahon, Lance
AU - Wellman, Paul J.
PY - 1993
Y1 - 1993
N2 - Activation of alpha-1 adrenoceptors, via systemic injection of agonists such as cirazoline and phenylpropanolamine (PPA), reliably suppresses food intake in rats. These effects are thought to result from stimulation of central α1-adrenoceptors within the rat paraventricular hypothalamic nucleus (PVN), based on studies in which direct injections of cirazoline, methoxamine, phenylephrine and PPA into PVN suppress food intake. Because relatively few α1-agonists have been tested to date using the systemic route of exposure, the preent study examined the effects of the α1-adrenoceptor agonists amidephrine and SKF-89748 on food and water intake. Adult male rats received systemic injections (IP) of either amidephrine (0.025, 0.05, 0.01 mg/kg) or of SK&F 89748 (0.01, 0.02, and 0.04 mg/kg). Amidephrine markedly suppressed food intake (ED50=0.49 mg/kg) and water intake (ED50=0.50 mg/kg), while SK&F 89748 marginally suppressed food intake (ED50=0.37 mg/kg) and was less potent in suppressing water intake (ED50=0.76 mg/kg). These results document that systemic injection of the α1-adrenoceptor agonists amidephrine and SK&F 89748 induces anorexia with amidephrine exerting greater potency than SK&F 89748. These results further support the hypothesis that stimulation of α1-adrenoceptors suppresses food intake.
AB - Activation of alpha-1 adrenoceptors, via systemic injection of agonists such as cirazoline and phenylpropanolamine (PPA), reliably suppresses food intake in rats. These effects are thought to result from stimulation of central α1-adrenoceptors within the rat paraventricular hypothalamic nucleus (PVN), based on studies in which direct injections of cirazoline, methoxamine, phenylephrine and PPA into PVN suppress food intake. Because relatively few α1-agonists have been tested to date using the systemic route of exposure, the preent study examined the effects of the α1-adrenoceptor agonists amidephrine and SKF-89748 on food and water intake. Adult male rats received systemic injections (IP) of either amidephrine (0.025, 0.05, 0.01 mg/kg) or of SK&F 89748 (0.01, 0.02, and 0.04 mg/kg). Amidephrine markedly suppressed food intake (ED50=0.49 mg/kg) and water intake (ED50=0.50 mg/kg), while SK&F 89748 marginally suppressed food intake (ED50=0.37 mg/kg) and was less potent in suppressing water intake (ED50=0.76 mg/kg). These results document that systemic injection of the α1-adrenoceptor agonists amidephrine and SK&F 89748 induces anorexia with amidephrine exerting greater potency than SK&F 89748. These results further support the hypothesis that stimulation of α1-adrenoceptors suppresses food intake.
UR - http://www.scopus.com/inward/record.url?scp=0027309382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027309382&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(93)90664-O
DO - 10.1016/0024-3205(93)90664-O
M3 - Article
C2 - 8100042
AN - SCOPUS:0027309382
VL - 53
SP - 169
EP - 174
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 2
ER -