Effects on food and water intake of the α1-adrenoceptor agonists amidephrine and SK&F-89748

Annie Morien, Lance McMahon, Paul J. Wellman

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Activation of alpha-1 adrenoceptors, via systemic injection of agonists such as cirazoline and phenylpropanolamine (PPA), reliably suppresses food intake in rats. These effects are thought to result from stimulation of central α1-adrenoceptors within the rat paraventricular hypothalamic nucleus (PVN), based on studies in which direct injections of cirazoline, methoxamine, phenylephrine and PPA into PVN suppress food intake. Because relatively few α1-agonists have been tested to date using the systemic route of exposure, the preent study examined the effects of the α1-adrenoceptor agonists amidephrine and SKF-89748 on food and water intake. Adult male rats received systemic injections (IP) of either amidephrine (0.025, 0.05, 0.01 mg/kg) or of SK&F 89748 (0.01, 0.02, and 0.04 mg/kg). Amidephrine markedly suppressed food intake (ED50=0.49 mg/kg) and water intake (ED50=0.50 mg/kg), while SK&F 89748 marginally suppressed food intake (ED50=0.37 mg/kg) and was less potent in suppressing water intake (ED50=0.76 mg/kg). These results document that systemic injection of the α1-adrenoceptor agonists amidephrine and SK&F 89748 induces anorexia with amidephrine exerting greater potency than SK&F 89748. These results further support the hypothesis that stimulation of α1-adrenoceptors suppresses food intake.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalLife Sciences
Volume53
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Adrenergic Receptors
Drinking
Eating
Water
Phenylpropanolamine
Rats
Injections
Paraventricular Hypothalamic Nucleus
Methoxamine
Direct injection
Anorexia
Phenylephrine
amidephrine
Chemical activation
cirazoline

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects on food and water intake of the α1-adrenoceptor agonists amidephrine and SK&F-89748. / Morien, Annie; McMahon, Lance; Wellman, Paul J.

In: Life Sciences, Vol. 53, No. 2, 1993, p. 169-174.

Research output: Contribution to journalArticle

Morien, Annie ; McMahon, Lance ; Wellman, Paul J. / Effects on food and water intake of the α1-adrenoceptor agonists amidephrine and SK&F-89748. In: Life Sciences. 1993 ; Vol. 53, No. 2. pp. 169-174.
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