Abstract
Activation of alpha-1 adrenoceptors, via systemic injection of agonists such as cirazoline and phenylpropanolamine (PPA), reliably suppresses food intake in rats. These effects are thought to result from stimulation of central α1-adrenoceptors within the rat paraventricular hypothalamic nucleus (PVN), based on studies in which direct injections of cirazoline, methoxamine, phenylephrine and PPA into PVN suppress food intake. Because relatively few α1-agonists have been tested to date using the systemic route of exposure, the preent study examined the effects of the α1-adrenoceptor agonists amidephrine and SKF-89748 on food and water intake. Adult male rats received systemic injections (IP) of either amidephrine (0.025, 0.05, 0.01 mg/kg) or of SK&F 89748 (0.01, 0.02, and 0.04 mg/kg). Amidephrine markedly suppressed food intake (ED50=0.49 mg/kg) and water intake (ED50=0.50 mg/kg), while SK&F 89748 marginally suppressed food intake (ED50=0.37 mg/kg) and was less potent in suppressing water intake (ED50=0.76 mg/kg). These results document that systemic injection of the α1-adrenoceptor agonists amidephrine and SK&F 89748 induces anorexia with amidephrine exerting greater potency than SK&F 89748. These results further support the hypothesis that stimulation of α1-adrenoceptors suppresses food intake.
Original language | English (US) |
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Pages (from-to) | 169-174 |
Number of pages | 6 |
Journal | Life Sciences |
Volume | 53 |
Issue number | 2 |
DOIs | |
State | Published - 1993 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)