Effects on food and water intake of the α1-adrenoceptor agonists amidephrine and SK&F-89748

Annie Morien, Lance McMahon, Paul J. Wellman

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Activation of alpha-1 adrenoceptors, via systemic injection of agonists such as cirazoline and phenylpropanolamine (PPA), reliably suppresses food intake in rats. These effects are thought to result from stimulation of central α1-adrenoceptors within the rat paraventricular hypothalamic nucleus (PVN), based on studies in which direct injections of cirazoline, methoxamine, phenylephrine and PPA into PVN suppress food intake. Because relatively few α1-agonists have been tested to date using the systemic route of exposure, the preent study examined the effects of the α1-adrenoceptor agonists amidephrine and SKF-89748 on food and water intake. Adult male rats received systemic injections (IP) of either amidephrine (0.025, 0.05, 0.01 mg/kg) or of SK&F 89748 (0.01, 0.02, and 0.04 mg/kg). Amidephrine markedly suppressed food intake (ED50=0.49 mg/kg) and water intake (ED50=0.50 mg/kg), while SK&F 89748 marginally suppressed food intake (ED50=0.37 mg/kg) and was less potent in suppressing water intake (ED50=0.76 mg/kg). These results document that systemic injection of the α1-adrenoceptor agonists amidephrine and SK&F 89748 induces anorexia with amidephrine exerting greater potency than SK&F 89748. These results further support the hypothesis that stimulation of α1-adrenoceptors suppresses food intake.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalLife Sciences
Volume53
Issue number2
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Effects on food and water intake of the α1-adrenoceptor agonists amidephrine and SK&F-89748'. Together they form a unique fingerprint.

  • Cite this