Effects of weather and season on human brain volume

Gregory A. Book, Shashwath A. Meda, Ronald Janssen, Alecia D. Dager, Andrew Poppe, Michael C. Stevens, Michal Assaf, David Glahn, Godfrey D. Pearlson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We present an exploratory cross-sectional analysis of the effect of season and weather on Freesurfer-derived brain volumes from a sample of 3,279 healthy individuals collected on two MRI scanners in Hartford, CT, USA over a 15 year period. Weather and seasonal effects were analyzed using a single linear regression model with age, sex, motion, scan sequence, time-of-day, month of the year, and the deviation from average barometric pressure, air temperature, and humidity, as covariates. FDR correction for multiple comparisons was applied to groups of non-overlapping ROIs. Significant negative relationships were found between the left- and right- cerebellum cortex and pressure (t = -2.25, p = 0.049; t = -2.771, p = 0.017). Significant positive relationships were found between left- and right- cerebellum cortex and white matter between the comparisons of January/June and January/September. Significant negative relationships were found between several subcortical ROIs for the summer months compared to January. An opposing effect was observed between the supraand infra-tentorium, with opposite effect directions in winter and summer. Cohen's d effect sizes from monthly comparisons were similar to those reported in recent psychiatric bigdata publications, raising the possibility that seasonal changes and weather may be confounds in large cohort studies. Additionally, changes in brain volume due to natural environmental variation have not been reported before and may have implications for weatherrelated and seasonal ailments.

Original languageEnglish (US)
Article numbere0236303
JournalPloS one
Issue number3 March
StatePublished - Mar 2021
Externally publishedYes

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Effects of weather and season on human brain volume'. Together they form a unique fingerprint.

Cite this