Effects of the Atypical Antipsychotics Amperozide and Clozapine on Behavior Maintained by Food, Cocaine, or Alfentanil in Rhesus Monkeys

Gail Winger, Eduardo Butelman

Research output: Contribution to journalArticle

Abstract

Amperozide and clozapine are antipsychotic drugs that act primarily as antagonists at 5-hydroxytryptamine (5HT2) sites. In different groups of rhesus monkeys (Macaca mulatta) receiving food, cocaine, or alfentanil as a consequence of responding on FR 30 schedules, the antipsychotic drugs produced dose-dependent decreases in behavior. Amperozide was more potent in suppressing food or cocaine-maintained responding than in suppressing alfentanil-maintained responding. Clozapine was nearly equally potent in suppressing behavior maintained by the different reinforcers. Neither drug showed a specificity of effect that suggests use in the treatment of cocaine or opioid abuse.

Original languageEnglish (US)
Pages (from-to)234-243
Number of pages10
JournalExperimental and Clinical Psychopharmacology
Volume2
Issue number3
DOIs
StatePublished - Aug 1994
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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