TY - JOUR
T1 - Effects of the Atypical Antipsychotics Amperozide and Clozapine on Behavior Maintained by Food, Cocaine, or Alfentanil in Rhesus Monkeys
AU - Winger, Gail
AU - Butelman, Eduardo
PY - 1994/8
Y1 - 1994/8
N2 - Amperozide and clozapine are antipsychotic drugs that act primarily as antagonists at 5-hydroxytryptamine (5HT2) sites. In different groups of rhesus monkeys (Macaca mulatta) receiving food, cocaine, or alfentanil as a consequence of responding on FR 30 schedules, the antipsychotic drugs produced dose-dependent decreases in behavior. Amperozide was more potent in suppressing food or cocaine-maintained responding than in suppressing alfentanil-maintained responding. Clozapine was nearly equally potent in suppressing behavior maintained by the different reinforcers. Neither drug showed a specificity of effect that suggests use in the treatment of cocaine or opioid abuse.
AB - Amperozide and clozapine are antipsychotic drugs that act primarily as antagonists at 5-hydroxytryptamine (5HT2) sites. In different groups of rhesus monkeys (Macaca mulatta) receiving food, cocaine, or alfentanil as a consequence of responding on FR 30 schedules, the antipsychotic drugs produced dose-dependent decreases in behavior. Amperozide was more potent in suppressing food or cocaine-maintained responding than in suppressing alfentanil-maintained responding. Clozapine was nearly equally potent in suppressing behavior maintained by the different reinforcers. Neither drug showed a specificity of effect that suggests use in the treatment of cocaine or opioid abuse.
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U2 - 10.1037/1064-1297.2.3.234
DO - 10.1037/1064-1297.2.3.234
M3 - Article
AN - SCOPUS:58149207989
VL - 2
SP - 234
EP - 243
JO - Experimental and Clinical Psychopharmacology
JF - Experimental and Clinical Psychopharmacology
SN - 1064-1297
IS - 3
ER -