Effects of the antiandrogen, cyproterone acetate, on the induction of papillomas, DNA synthesis and ornithine decarboxylase activity in mouse skin

K. A. Davidson, L. Ewald, A. Herrmann, S. P. Ogle, Thomas J Slaga

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The antiandrogen, cyproterone acetate (CPA), applied simultaneously with 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal skin of male and female SENCAR mice initiated with 7, 12-dimethylbenz[a]anthracene inhibited the production of papillomas of the skin. Although 125 and 250 μg of CPA had no effect on the incidence of papillomas per mouse, 500 μg of CPA inhibited papilloma production by 95% and 91% in female mice after 20 and 37 weeks of promotion, respectively. Testosterone propionate only partially blocked the inhibitory effect of CPA. In male mice 500 μg and 1 mg of CPA inhibited papilloma production by 77% and 88%, respectively. In the two-stage promotion protocol 500 μg of CPA was ineffective as an inhibitor when it was applied with TPA during the 1st stage but inhibited papilloma production by 71% when it was applied with mezerein during the 2nd stage. CPA was also observed to inhibit TPA-stimulated epidermal DNA synthesis and inflammation but had no effect on TPA-induced epidermal ornithine decar-boxylase activity.

Original languageEnglish (US)
Pages (from-to)609-614
Number of pages6
JournalCarcinogenesis
Volume5
Issue number5
DOIs
StatePublished - May 1984
Externally publishedYes

Fingerprint

Cyproterone Acetate
Androgen Antagonists
Ornithine Decarboxylase
Papilloma
Skin
Mouse
Proof by induction
DNA
Synthesis
Tetradecanoylphorbol Acetate
Inflammation
Anthracene
Inbred SENCAR Mouse
Inhibitor
Incidence
Testosterone Propionate
Ornithine
Induction
Promotion

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience
  • Cancer Research

Cite this

Effects of the antiandrogen, cyproterone acetate, on the induction of papillomas, DNA synthesis and ornithine decarboxylase activity in mouse skin. / Davidson, K. A.; Ewald, L.; Herrmann, A.; Ogle, S. P.; Slaga, Thomas J.

In: Carcinogenesis, Vol. 5, No. 5, 05.1984, p. 609-614.

Research output: Contribution to journalArticle

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