TY - JOUR
T1 - Effects of synthetic craniofacial materials on cerebral microcirculation
AU - Barone, Constance M.
AU - Jimenez, David F.
AU - Beckert, Benjamin W.
AU - Clapper, Adam T.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Four groups were studied to look at effects of synthetic materials on the pial vasculature. Using Sprague-Dawley rats, an open pial window approach was used in which there was a control group, a hydroxyapatite cement group mixed with sodium phosphate, a methylmethacrylate slow-set, and a methylmethacrylate fast-set group. There were 10 animals with 20 vessels studied within each group. The permeability leakage outside the vessel was evaluated to determine the vascular albumin leakage, and the number of rolling and adherent leukocytes was studied within each group. It was seen that the control group was significantly different compared with the fast-set methylmethacrylate group during a 2-hour period in regard to the percentage leakage, as well as a number of rolling and adherent leukocytes. This is one of the first studies to demonstrate the effects of synthetic craniofacial materials on the underlying pial vasculature.
AB - Four groups were studied to look at effects of synthetic materials on the pial vasculature. Using Sprague-Dawley rats, an open pial window approach was used in which there was a control group, a hydroxyapatite cement group mixed with sodium phosphate, a methylmethacrylate slow-set, and a methylmethacrylate fast-set group. There were 10 animals with 20 vessels studied within each group. The permeability leakage outside the vessel was evaluated to determine the vascular albumin leakage, and the number of rolling and adherent leukocytes was studied within each group. It was seen that the control group was significantly different compared with the fast-set methylmethacrylate group during a 2-hour period in regard to the percentage leakage, as well as a number of rolling and adherent leukocytes. This is one of the first studies to demonstrate the effects of synthetic craniofacial materials on the underlying pial vasculature.
KW - Hydroxyapatite cement
KW - Methylmethacrylate
KW - Synthetic cranioplasty
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U2 - 10.1097/00001665-200103000-00017
DO - 10.1097/00001665-200103000-00017
M3 - Article
C2 - 11314631
AN - SCOPUS:0035746231
VL - 12
SP - 191
EP - 193
JO - Journal of Craniofacial Surgery
JF - Journal of Craniofacial Surgery
SN - 1049-2275
IS - 2
ER -