Effects of 32P radioactive stents on in-stent restenosis in a double stent injury model of the porcine coronary arteries

Han Soo Kim, Rosanna C. Chan, Marc Kollum, Arthur Au, Fermin O. Tio, Hamid A. Yazdi, Andrew E. Ajani, Ron Waksman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: The major limitation of coronary stenting remains in-stent restenosis, due to the development of neointimal proliferation. Radioactive stents have demonstrated the ability to reduce this proliferation in the healthy nonatherosclerotic porcine animal model. However, inhibition of tissue proliferation in the in-stent restenotic lesion in a porcine model is not well characterized. The objective of this study was to examine the efficacy and safety of the 32P radioactive stent for the treatment of in-stent restenosis in a double stent injury model of the porcine coronaries. Methods and Materials: Eighteen coronary arteries in 9 pigs underwent nonradioactive stent (8 mm in length) implantation. Thirty days after the initial stent implantation, a 32P radioactive stent (18 mm in length) with an activity of 0 and 18 μCi was implanted to cover the initial stent. The swine were killed 30 days after the second stent implantation. Histomorphometric analysis was performed for vessel area (VA), stent strut area (SSA), intimal area (IA), and lumen area (LA). Results: Injury scores, VA, SSA, and LA were similar among the control and radiated groups. Neointimal formation was significantly reduced after placement of radioactive stents as compared to control in both the overlapped (0.93 ± 0.12 vs. 1.31 ± 0.51 mm2, p < 0.05) and nonoverlapped segments (1.14 ± 0.21 vs. 1.91 ± 1.04 mm2, p < 0.05). The smooth muscle cell index in the neointima was reduced. Intimal fibrin was increased in the radiated group as compared to the control (p < 0.01 respectively). Conclusions: 32P radioactive stents may be safe and effective in reducing neointimal formation leading to in-stent restenosis. Longer follow-up will be required to examine whether these positive findings can be maintained.

Original languageEnglish (US)
Pages (from-to)1058-1063
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume51
Issue number4
DOIs
StatePublished - Nov 15 2001
Externally publishedYes

Keywords

  • Beta radiation
  • Brachytherapy
  • In-stent restenosis
  • Radioactive stent

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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