Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing

Mark I. Ryder, Barbara Pons, Donald Adams, Bradley Beiswanger, Valerie Blanco, Gary Bogle, Kevin Donly, William Hallmon, E. Brady Hancock, Philip Hanes, Charles Hawley, Lonnie Johnson, Horn Lay Wang, Lawrence Wolinsky, Raymond Yukna, Alan Polson, Graham Carron, Steven Garrett

Research output: Contribution to journalArticle

40 Scopus citations


This paper examines the effects of smoking on the treatment outcomes of two nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled-release of subgingivally delivered doxycycline hyclate in a polylactic acid based polymer gel. Subjects from 2 9-month multicenter studies were classified as nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current smokers (≥ 10 cigarettes/day: 121 subjects). Clinical parameters were analyzed for treated sites with baseline probing depths ≥5 mm and for a subset of treated sites with baseline probing depths of ≥7 mm. Clinical parameters (plaque levels, clinical attachment levels, pocket depths, and bleeding on probing) were analyzed at baseline, 4, 6, and 9 months. In the doxycycline treated group in general, there were neither marked significant differences in clinical attachment gain nor differences in probing depth reduction among the 3 smoking groups. On the other hand, in the scaling and root planing treated group in general, there were significant differences in clinical attachment gain and pocket depth reduction, with non-smokers responding better than former smokers and current smokers at 6 and 9 months. These differences in clinical response between scaling and root planing alone versus controlled-release of locally-delivered doxycycline hyclate among these 3 smoking groups are discussed in relation to treatment implications for smokers.

Original languageEnglish (US)
Pages (from-to)683-691
Number of pages9
JournalJournal of Clinical Periodontology
Issue number10
Publication statusPublished - Oct 1999



  • Doxycycline
  • Local delivery
  • Periodontitis
  • Scaling/root planing
  • Tobacco

ASJC Scopus subject areas

  • Periodontics

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