Effects of seven clinically important antiepileptic drugs on inhibitory glycine receptor currents in hippocampal neurons

Kameel M. Karkar, Liu Lin Thio, Kelvin A. Yamada

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Although potentiation of the inhibitory glycine receptor (GlyR) may contribute to the mechanism of action of antiepileptic drugs (AEDs), the effects of AEDs on GlyRs have not been investigated in detail in forebrain neurons. We examined the effects of seven clinically important AEDs on GlyR-mediated currents using whole-cell patch clamp recordings from cultured embryonic mouse hippocampal neurons. At high therapeutic concentrations, topiramate (in 24% of neurons) and pentobarbital reversibly decreased glycine currents to 78±6% and 81±7% of control, respectively. At or below therapeutic concentrations, carbamazepine, felbamate, gabapentin, phenytoin, and valproate had no effect on glycine currents, while at supratherapeutic concentrations these agents produced modest reversible inhibition. We conclude that GlyR potentiation does not contribute to the antiepileptic action of the seven AEDs examined.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalEpilepsy Research
Volume58
Issue number1
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

Keywords

  • Carbamazepine
  • Felbamate
  • Gabapentin
  • Pentobarbital
  • Phenytoin
  • Topiramate
  • Valproate

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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