Effects of selective hepatic vagotomy on running endurance in rats

B. Doiron, S. Cardin, G. R. Brisson, J. M. Lavoie

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The liver, through the afferent ways of the vagus hepatic nerve, may influence metabolic adaptations during exercise. This study assesses the functional significance of this hepatic innervation by determining the effect of a selective hepatic vagotomy (HV) on running endurance time during submaximal activity in rats subjected to an overnight 50% food restriction. The time to exhaustion was similar for the groups of HV and sham-operated (SHM) rats [66 ± 15 vs. 64 ± 21 (SD) min]. The HV group was associated with higher resting levels (P < 0.05) of hepatic glycogen and plasma glucose. No significant differences were observed between HV and SHM rats at rest and after exercise for muscle glycogen, free fatty acids, insulin, glucagon, and lactate concentrations. These data indicate that if hepatic glucoreceptors do exist and contribute to the metabolic regulation of exercise, their functional significance is secondary to more important regulatory mechanisms.

Original languageEnglish (US)
Pages (from-to)2197-2201
Number of pages5
JournalJournal of applied physiology
Issue number6
StatePublished - 1990
Externally publishedYes


  • free fatty acids
  • glucagon
  • hepatic glucoreceptors
  • insulin
  • liver glycogen
  • muscle glycogen

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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