Effects of selective hepatic vagotomy on running endurance in rats

Bruno Doiron, S. Cardin, G. R. Brisson, J. M. Lavoie

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The liver, through the afferent ways of the vagus hepatic nerve, may influence metabolic adaptations during exercise. This study assesses the functional significance of this hepatic innervation by determining the effect of a selective hepatic vagotomy (HV) on running endurance time during submaximal activity in rats subjected to an overnight 50% food restriction. The time to exhaustion was similar for the groups of HV and sham-operated (SHM) rats [66 ± 15 vs. 64 ± 21 (SD) min]. The HV group was associated with higher resting levels (P < 0.05) of hepatic glycogen and plasma glucose. No significant differences were observed between HV and SHM rats at rest and after exercise for muscle glycogen, free fatty acids, insulin, glucagon, and lactate concentrations. These data indicate that if hepatic glucoreceptors do exist and contribute to the metabolic regulation of exercise, their functional significance is secondary to more important regulatory mechanisms.

Original languageEnglish (US)
Pages (from-to)2197-2201
Number of pages5
JournalJournal of Applied Physiology
Volume69
Issue number6
StatePublished - 1990
Externally publishedYes

Fingerprint

Vagotomy
Liver
Liver Glycogen
Vagus Nerve
Glucagon
Glycogen
Nonesterified Fatty Acids
Lactic Acid
Insulin
Glucose
Food
Muscles

Keywords

  • free fatty acids
  • glucagon
  • hepatic glucoreceptors
  • insulin
  • liver glycogen
  • muscle glycogen

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Doiron, B., Cardin, S., Brisson, G. R., & Lavoie, J. M. (1990). Effects of selective hepatic vagotomy on running endurance in rats. Journal of Applied Physiology, 69(6), 2197-2201.

Effects of selective hepatic vagotomy on running endurance in rats. / Doiron, Bruno; Cardin, S.; Brisson, G. R.; Lavoie, J. M.

In: Journal of Applied Physiology, Vol. 69, No. 6, 1990, p. 2197-2201.

Research output: Contribution to journalArticle

Doiron, B, Cardin, S, Brisson, GR & Lavoie, JM 1990, 'Effects of selective hepatic vagotomy on running endurance in rats', Journal of Applied Physiology, vol. 69, no. 6, pp. 2197-2201.
Doiron B, Cardin S, Brisson GR, Lavoie JM. Effects of selective hepatic vagotomy on running endurance in rats. Journal of Applied Physiology. 1990;69(6):2197-2201.
Doiron, Bruno ; Cardin, S. ; Brisson, G. R. ; Lavoie, J. M. / Effects of selective hepatic vagotomy on running endurance in rats. In: Journal of Applied Physiology. 1990 ; Vol. 69, No. 6. pp. 2197-2201.
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