EFFECTS OF SARS COVID-19 POSITIVITY STATUS ON VENOUS THROMBOSIS AND PULMONARY EMBOLISM RATES IN TRAUMA PATIENTS

Connor L. Kenney; Austin R. Nelson; Ryan A. Fahey; Daniel J. Roubik; Remealle A. How; Jason S. Radowsky; Valerie G. Sams; Steven G. Schauer; Julie A. Rizzo

doi:10.1097/SHK.0000000000002097

EFFECTS OF SARS COVID-19 POSITIVITY STATUS ON VENOUS THROMBOSIS AND PULMONARY EMBOLISM RATES IN TRAUMA PATIENTS

Connor L. Kenney, Austin R. Nelson, Ryan A. Fahey, Daniel J. Roubik, Remealle A. How, Jason S. Radowsky, Valerie G. Sams, Steven G. Schauer, Julie A. Rizzo

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Introduction: COVID-19-induced coagulopathy (CIC) can increase the risk of thromboembolism without underlying clotting disorders, even when compared with other respiratory viruses. Trauma has a known association with hypercoagulability. Trauma patients with concurrent COVID-19 infection potentially have an even greater risk of thrombotic events. The purpose of this study was to evaluate venous thromboembolism (VTE) rates in trauma patients with COVID-19. Methods: This study reviewed all adult patients (≥18 years of age) admitted to the Trauma Service from April through November 2020 for a minimum of 48 hours. Patients were grouped based off COVID-19 status and compared for inpatient VTE chemoprophylaxis regimen, thrombotic complications defined as deep vein thrombosis, pulmonary embolism, myocardial infarction, and cerebrovascular accident, intensive care unit (ICU) length of stay, hospital length of stay, and mortality. Results: A total of 2,907 patients were reviewed and grouped into COVID-19-positive (n = 110) and COVID-19-negative (n = 2,797) groups. There was no difference in terms of receiving deep vein thrombosis chemoprophylaxis or type, but a longer time to initiation in the positive group (P = 0.0012). VTE occurred in 5 (4.55%) positive and 60 (2.15%) negative patients without a significant difference between the groups, as well as no difference in type of VTE observed. Mortality was higher (P = 0.009) in the positive group (10.91%). Positive patients had longer median ICU LOS (P = 0.0012) and total LOS (P < 0.001). Conclusion: There were no increased rates of VTE complications between COVID-19-positive and -negative trauma patients, despite a longer time to initiation of chemoprophylaxis in the COVID-19-positive group. COVID-19-positive patients had increased ICU LOS, total LOS, and mortality, which are likely due to multifactorial causes but primarily related to their underlying COVID-19 infection.

Original language	English (US)
Pages (from-to)	599-602
Number of pages	4
Journal	Shock
Volume	59
Issue number	4
DOIs	https://doi.org/10.1097/SHK.0000000000002097
State	Published - Apr 1 2023
Externally published	Yes

Keywords

COVID-19
clot
hypercoagulability
trauma
venous thromboembolism

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine
Emergency Medicine

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10.1097/SHK.0000000000002097

Cite this

@article{6f55014523df444b83061befecdd6a42,

title = "EFFECTS OF SARS COVID-19 POSITIVITY STATUS ON VENOUS THROMBOSIS AND PULMONARY EMBOLISM RATES IN TRAUMA PATIENTS",

abstract = "Introduction: COVID-19-induced coagulopathy (CIC) can increase the risk of thromboembolism without underlying clotting disorders, even when compared with other respiratory viruses. Trauma has a known association with hypercoagulability. Trauma patients with concurrent COVID-19 infection potentially have an even greater risk of thrombotic events. The purpose of this study was to evaluate venous thromboembolism (VTE) rates in trauma patients with COVID-19. Methods: This study reviewed all adult patients (≥18 years of age) admitted to the Trauma Service from April through November 2020 for a minimum of 48 hours. Patients were grouped based off COVID-19 status and compared for inpatient VTE chemoprophylaxis regimen, thrombotic complications defined as deep vein thrombosis, pulmonary embolism, myocardial infarction, and cerebrovascular accident, intensive care unit (ICU) length of stay, hospital length of stay, and mortality. Results: A total of 2,907 patients were reviewed and grouped into COVID-19-positive (n = 110) and COVID-19-negative (n = 2,797) groups. There was no difference in terms of receiving deep vein thrombosis chemoprophylaxis or type, but a longer time to initiation in the positive group (P = 0.0012). VTE occurred in 5 (4.55%) positive and 60 (2.15%) negative patients without a significant difference between the groups, as well as no difference in type of VTE observed. Mortality was higher (P = 0.009) in the positive group (10.91%). Positive patients had longer median ICU LOS (P = 0.0012) and total LOS (P < 0.001). Conclusion: There were no increased rates of VTE complications between COVID-19-positive and -negative trauma patients, despite a longer time to initiation of chemoprophylaxis in the COVID-19-positive group. COVID-19-positive patients had increased ICU LOS, total LOS, and mortality, which are likely due to multifactorial causes but primarily related to their underlying COVID-19 infection.",

keywords = "COVID-19, clot, hypercoagulability, trauma, venous thromboembolism",

author = "Kenney, {Connor L.} and Nelson, {Austin R.} and Fahey, {Ryan A.} and Roubik, {Daniel J.} and How, {Remealle A.} and Radowsky, {Jason S.} and Sams, {Valerie G.} and Schauer, {Steven G.} and Rizzo, {Julie A.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 by the Shock Society.",

year = "2023",

month = apr,

day = "1",

doi = "10.1097/SHK.0000000000002097",

language = "English (US)",

volume = "59",

pages = "599--602",

journal = "Shock",

issn = "1073-2322",

publisher = "Lippincott Williams and Wilkins",

number = "4",

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TY - JOUR

T1 - EFFECTS OF SARS COVID-19 POSITIVITY STATUS ON VENOUS THROMBOSIS AND PULMONARY EMBOLISM RATES IN TRAUMA PATIENTS

AU - Kenney, Connor L.

AU - Nelson, Austin R.

AU - Fahey, Ryan A.

AU - Roubik, Daniel J.

AU - How, Remealle A.

AU - Radowsky, Jason S.

AU - Sams, Valerie G.

AU - Schauer, Steven G.

AU - Rizzo, Julie A.

PY - 2023/4/1

Y1 - 2023/4/1

N2 - Introduction: COVID-19-induced coagulopathy (CIC) can increase the risk of thromboembolism without underlying clotting disorders, even when compared with other respiratory viruses. Trauma has a known association with hypercoagulability. Trauma patients with concurrent COVID-19 infection potentially have an even greater risk of thrombotic events. The purpose of this study was to evaluate venous thromboembolism (VTE) rates in trauma patients with COVID-19. Methods: This study reviewed all adult patients (≥18 years of age) admitted to the Trauma Service from April through November 2020 for a minimum of 48 hours. Patients were grouped based off COVID-19 status and compared for inpatient VTE chemoprophylaxis regimen, thrombotic complications defined as deep vein thrombosis, pulmonary embolism, myocardial infarction, and cerebrovascular accident, intensive care unit (ICU) length of stay, hospital length of stay, and mortality. Results: A total of 2,907 patients were reviewed and grouped into COVID-19-positive (n = 110) and COVID-19-negative (n = 2,797) groups. There was no difference in terms of receiving deep vein thrombosis chemoprophylaxis or type, but a longer time to initiation in the positive group (P = 0.0012). VTE occurred in 5 (4.55%) positive and 60 (2.15%) negative patients without a significant difference between the groups, as well as no difference in type of VTE observed. Mortality was higher (P = 0.009) in the positive group (10.91%). Positive patients had longer median ICU LOS (P = 0.0012) and total LOS (P < 0.001). Conclusion: There were no increased rates of VTE complications between COVID-19-positive and -negative trauma patients, despite a longer time to initiation of chemoprophylaxis in the COVID-19-positive group. COVID-19-positive patients had increased ICU LOS, total LOS, and mortality, which are likely due to multifactorial causes but primarily related to their underlying COVID-19 infection.

AB - Introduction: COVID-19-induced coagulopathy (CIC) can increase the risk of thromboembolism without underlying clotting disorders, even when compared with other respiratory viruses. Trauma has a known association with hypercoagulability. Trauma patients with concurrent COVID-19 infection potentially have an even greater risk of thrombotic events. The purpose of this study was to evaluate venous thromboembolism (VTE) rates in trauma patients with COVID-19. Methods: This study reviewed all adult patients (≥18 years of age) admitted to the Trauma Service from April through November 2020 for a minimum of 48 hours. Patients were grouped based off COVID-19 status and compared for inpatient VTE chemoprophylaxis regimen, thrombotic complications defined as deep vein thrombosis, pulmonary embolism, myocardial infarction, and cerebrovascular accident, intensive care unit (ICU) length of stay, hospital length of stay, and mortality. Results: A total of 2,907 patients were reviewed and grouped into COVID-19-positive (n = 110) and COVID-19-negative (n = 2,797) groups. There was no difference in terms of receiving deep vein thrombosis chemoprophylaxis or type, but a longer time to initiation in the positive group (P = 0.0012). VTE occurred in 5 (4.55%) positive and 60 (2.15%) negative patients without a significant difference between the groups, as well as no difference in type of VTE observed. Mortality was higher (P = 0.009) in the positive group (10.91%). Positive patients had longer median ICU LOS (P = 0.0012) and total LOS (P < 0.001). Conclusion: There were no increased rates of VTE complications between COVID-19-positive and -negative trauma patients, despite a longer time to initiation of chemoprophylaxis in the COVID-19-positive group. COVID-19-positive patients had increased ICU LOS, total LOS, and mortality, which are likely due to multifactorial causes but primarily related to their underlying COVID-19 infection.

KW - COVID-19

KW - clot

KW - hypercoagulability

KW - trauma

KW - venous thromboembolism

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EFFECTS OF SARS COVID-19 POSITIVITY STATUS ON VENOUS THROMBOSIS AND PULMONARY EMBOLISM RATES IN TRAUMA PATIENTS

Abstract

Keywords

ASJC Scopus subject areas

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