Effects of rosuvastatin on electronegative LDL as characterized by capillary isotachophoresis: The ROSARY Study

Bo Zhang, Akira Matsunaga, David L. Rainwater, Shin Ichiro Miura, Keita Noda, Hiroaki Nishikawa, Yoshinari Uehara, Kazuyuki Shirai, Masahiro Ogawa, Keijiro Saku

    Research output: Contribution to journalArticlepeer-review

    32 Scopus citations

    Abstract

    Electronegative LDL, a charge-modified LDL (cm-LDL) subfraction that is more negatively charged than normal LDL, has been shown to be inflammatory. We previously showed that pravastatin and simvastatin reduced the electronegative LDL subfraction, fast-migrating LDL (fLDL), as analyzed by capillary isotachophoresis (cITP). The present study examined the effects of rosuvastatin on the more electronegative LDL subfraction, very-fast-migrating LDL (vfLDL), and small, dense charge-modified LDL (sd-cm-LDL) subfractions. Patients with hypercholesterolemia or those who were being treated with statins (n = 81) were treated with or switched to 2.5 mg/d rosuvastatin for 3 months. Rosuvastatin treatment effectively reduced cITP cm-LDL subfractions of LDL (vfLDL and fLDL) or sdLDL (sd-vfLDL and sd-fLDL), which were closely related to each other but were different from the normal subfraction of LDL [slow-migrating LDL (sLDL)] or sdLDL (sd-sLDL) in their relation to the levels of remnant-like particle cholesterol (RLP-C), apolipoprotein (apo) C-II, and apoE. The percent changes in cm-LDL or sd-cm-LDL caused by rosuvastatin were correlated with those in the particle concentrations of LDL or sdLDL measured as LDL-apoB or sdLDL-apoB and the levels of HDL-C, RLP-C, apoC-II, and apoE. In conclusion, rosuvastatin effectively reduced both the vfLDL subfraction and sd-cm-LDL subfractions as analyzed by cITP.

    Original languageEnglish (US)
    Pages (from-to)1832-1841
    Number of pages10
    JournalJournal of lipid research
    Volume50
    Issue number9
    DOIs
    StatePublished - 2009

    Keywords

    • Hypercholesterolemia
    • LDL particle concentrations
    • Small dense LDL
    • Statins

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Cell Biology

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