Effects of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis: A multi-center, randomized, placebo-controlled clinical trial

Jian Li Liu, Han Min Zhu, Qi Ren Huang, Zhong Lan Zhang, Hui Lin Li, Yue Juan Qin, Ying Zhang, Dao Lin Wei, Jing Hui Lu, Hui Liu, Xiao Ping Chen, Yu Juan Liu, Abie Ekangaki, Yi Man Zheng, Adolfo Diez-Perez, Kristine Harper

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background. Raloxifene has been approved for prevention and treatment of postmenopausal osteoporosis in Caucasian women. It also has some positive effects on serum lipids in Caucasians. The objective of this study was to determine the effect of raloxifene hydrochloride on lumbar spine and total hip bone mineral density (BMD), bone metabolism, and serum lipids in Chinese postmenopausal women with osteoporosis. Methods. This was a multi-center, randomized, double-blind, placebo-controlled clinical trial in which 204 postmenopausal Chinese women with osteoporosis were assigned to receive raloxifene (60 mg) or placebo treatment daily for 12 months. BMD, serum bone metabolism markers, and serum lipids were measured before and after drug administration. BMD was measured by Dual-Energy X-Ray Absorptiometry (DEXA) and bone metabolism markers were analyzed by one-step enzyme-linked immunosorbent assay. Serum lipids were measured by enzymatic analysis. Results. At the end of the 12-month study, lumbar spine BMD intreased in both groups with a mean increase of (3.3 ±4.8) % in the raloxifene group and (1.0 ±4.9 ) % in the placebo group (P < 0.001). There was a mean increase in total hip BMD of (1.4 ±4.8) % in the raloxifene group and a mean decrease of (0.9 ±5.0) % in the placebo group (P < 0.001 ). No subject in the raloxifene group had a new vertebral fracture and 5 placebo subjects had new fractures (P > 0.05). In the raloxifene group, the median decreases in the biochemical markers of bone metabolism serum osteocalcin and C-telopeptide were 41.7% and 61.5%, respectively. These changes ware statistically significant compared with those in the placebo group (10.6% and 35.6%, P <0.001, respectively). Both total cholesterol and low-density lipoprotein cholesterol decreased significantly in the raloxifene group compared with those in the placebo group (P <0.001, respectively) and there was no significant effect of raloxifene on high-density lipoprotein cholesterol and triglycerides compared with placebo. Conclusions. Raloxifene 60 mg/d for 12 months significantly increases lumbar spine and total hip BMD, significantly decreases bone turnover, and has favourable effects on serum lipids in Chinese postmenopausal women with osteoporosis.

Original languageEnglish (US)
Pages (from-to)1029-1035
Number of pages7
JournalChinese Medical Journal
Volume117
Issue number7
StatePublished - Jul 2004
Externally publishedYes

Keywords

  • Bone density
  • Bone metabolism markers
  • Osteoporosis, postmenopausal
  • Raloxifene

ASJC Scopus subject areas

  • General Medicine

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