TY - JOUR
T1 - Effects of oxygen and ventilation on pulmonary mechanics and ultrastructure during cardiopulmonary bypass
AU - Weedn, Robert J.
AU - Coalson, Jacqueline J.
AU - Greenfield, Lazar J.
N1 - Funding Information:
From the Departments of Surgery and Pathology, University of Oklahoma Medical Center, 800 NE ]3th Street, Oklahoma City, Oklahoma, and the Veterans Administration Hospital, 92! NE ]3th Street, Oklahoma City. Oklahoma 73104. This work was supported in part by, Utd Navy Contract N000t4-68-A-0496, US Public Health Service Grant, HE ! 1575-02. and the Markle Foundation (Dr Greenfield). Presented at the Twenty.Second Annual Meeting of the Southwestern Surgical Congress, Dallas, Texas, April 20-23, 1970.
PY - 1970/11
Y1 - 1970/11
N2 - The effects of three different methods of ventilation on pulmonary pathology during cardiopulmonary bypass are evaluated in twenty-one dogs in terms of lung mechanics and light and electron microscopy. Although air pressure-volume studies revealed essentially equal degrees of impairment resulting from all three methods, there was less ultrastructural damage when the lungs were statically inflated with 100 per cent oxygen during the bypass period. This evidence suggests that static 100 per cent oxygen inflation is of more value in preventing the initial pathologic change leading to development of the post-perfusion lung syndrome than either intermittent ventilation or static deflation.
AB - The effects of three different methods of ventilation on pulmonary pathology during cardiopulmonary bypass are evaluated in twenty-one dogs in terms of lung mechanics and light and electron microscopy. Although air pressure-volume studies revealed essentially equal degrees of impairment resulting from all three methods, there was less ultrastructural damage when the lungs were statically inflated with 100 per cent oxygen during the bypass period. This evidence suggests that static 100 per cent oxygen inflation is of more value in preventing the initial pathologic change leading to development of the post-perfusion lung syndrome than either intermittent ventilation or static deflation.
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U2 - 10.1016/S0002-9610(70)80172-6
DO - 10.1016/S0002-9610(70)80172-6
M3 - Article
C2 - 5489707
AN - SCOPUS:0014873189
VL - 120
SP - 584
EP - 590
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 5
ER -