Effects of oral administration of Stephania tetrandra S. Moore on neovascularization of retinal and choroidal capillaries of diabetes in rats

Taiki Tsutsumi, Nobuyoshi Hagino, Xiao Chun Liang, Sai Shan Guo, Shinjiro Kobayashi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In rats, an injection of streptozotocin (STZ) elevated blood levels of glucose 4 weeks later (STZ-induced diabetes) and an over-production of microvessels of retinal and choroidal capillaries of eyes developed. A previous study has shown that administration of Stephania tetrandra S. Moore (STSM) in culture prevented the over-production of microvessels of those capillaries of STZ-induced diabetes in vitro. Therefore, the study investigated whether or not orally administered STSM could inhibit over-production of microvessels of those capillaries of STZ injected rats in vivo. When STSM was given at the same time as the STZ injection and continued daily for 7 weeks, STSM prevented the elevation of blood glucose level and over-production of microvessels of those capillaries. When STSM was given after elevation of blood glucose level of glucose (4 weeks after STZ injection) and continued daily for 4 weeks, STSM lowered the elevated blood glucose level but had no effect on the over-production of microvessels of those capillaries. It was inferred that deposition of Nε(carboxymethyl) lysine in retinal and choroidal tissues, which is induced by STZ-induced diabetes may deteriorate the blood-retinal barrier and the blood-choroidal barrier. One might, therefore, speculate that advanced STZ-induced diabetes may deteriorate the blood-retinal barrier and blood-choroidal barrier. Therefore, STSM may not reach the retinal and choroidal tissues in the posterior ocular region in vivo.

Original languageEnglish (US)
Pages (from-to)591-596
Number of pages6
JournalPhytotherapy Research
Volume22
Issue number5
DOIs
StatePublished - May 2008

Keywords

  • Choroid
  • Diabetes
  • Neovascularization
  • Rats
  • Retina
  • Stephania tetrandra S. Moore

ASJC Scopus subject areas

  • Pharmacology

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