Effects of nutrition on disease and life span. I. Immune responses, cardiovascular pathology, and life span in MRL mice

D. A. Mark, D. R. Alonso, F. Quimby, H. T. Thaler, Y. T. Kim, G. Fernandes, R. A. Good, M. E. Weksler

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Abstract

Mice of the autoimmune, lymphoproliferative strain MRL/lpr and the congenic, nonlymphoproliferative strain MRL/n were fed one of six diets from weaning onward. These mice were sacrificed at 3 or 5 months of age. Low fat diets resulted in lower cholesterol and higher triglyceride levels than did cholesterol-containing high-fat diets. Caloric restriction of MRL/lpr mice was associated with an increased plaque-forming cell response to trinitrophenylated polyacrylamide beads, less lymphoproliferation, and less severe glomerulonephritis. Diet did not affect the incidence of autoimmune vasculitis in MRL/lpr mice sacrificed at 5 months. MRL/lpr mice fed a low-fat, calorically restricted diet from 5 months of age to death lived longer than mice which were fed ad libitum a cholesterol-containing, high-fed diet. At death, MRL/lpr mice fed the former diet had the autoimmune vasculitis which had been evident in mice killed at 5 months, whereas mice fed the latter diet, in addition to the vasculitis, had a high incidence of atherosclerotic lesions of intrarenal and aortic branch arteries.

Original languageEnglish (US)
Pages (from-to)110-124
Number of pages15
JournalAmerican Journal of Pathology
Volume117
Issue number1
StatePublished - Dec 1 1984

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Mark, D. A., Alonso, D. R., Quimby, F., Thaler, H. T., Kim, Y. T., Fernandes, G., Good, R. A., & Weksler, M. E. (1984). Effects of nutrition on disease and life span. I. Immune responses, cardiovascular pathology, and life span in MRL mice. American Journal of Pathology, 117(1), 110-124.