Abstract
Decreased consumption of n-3 fatty acids (FA) and diets rich in animal proteins, saturated fats and n-6 vegetable oils are associated with a higher incidence of cardiovascular disease (CVD), certain malignancies and autoimmune disorders such as rheumatoid arthritis and Systemic Lupus Erythromatous (SLE), and renal disease. Recent studies show that reduced calorie intake and supplementation of diet with n-3 FA delays the onset of autoimmune renal disease, primarily, due to increased antioxidant enzyme activities, decreased NF-kappaB activation and decreased IL-I, IL-6 and TNF-alpha mRNA expression in the kidney tissue. Studies in rodents show that addition of n-3 FA and soy protein to diet affords protection against bone loss induced by ovariectomy in mice due to NF-kappaB expression and decreased activation of osteoclasts. Together, the availale evidence show that increased daily intake of dietary n-3 FA decreases the severity of autoimmune disorders, lessens the chance of developing CVD, and protects against bone loss during post-menopause.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4015-4020 |
| Number of pages | 6 |
| Journal | Frontiers in Bioscience |
| Volume | 13 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2008 |
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Keywords
- Autoimmunity
- N-3 fatty acids
- Osteoporosis
- Review
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology
Cite this
Effects of n-3 fatty acids on autoimmunity and osteoporosis. / Fernandes, Gabriel; Bhattacharya, Arunabh; Rahman, Mizanur; Zaman, Khaliquz; Banu, Jameela.
In: Frontiers in Bioscience, Vol. 13, No. 11, 2008, p. 4015-4020.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of n-3 fatty acids on autoimmunity and osteoporosis
AU - Fernandes, Gabriel
AU - Bhattacharya, Arunabh
AU - Rahman, Mizanur
AU - Zaman, Khaliquz
AU - Banu, Jameela
PY - 2008
Y1 - 2008
N2 - Decreased consumption of n-3 fatty acids (FA) and diets rich in animal proteins, saturated fats and n-6 vegetable oils are associated with a higher incidence of cardiovascular disease (CVD), certain malignancies and autoimmune disorders such as rheumatoid arthritis and Systemic Lupus Erythromatous (SLE), and renal disease. Recent studies show that reduced calorie intake and supplementation of diet with n-3 FA delays the onset of autoimmune renal disease, primarily, due to increased antioxidant enzyme activities, decreased NF-kappaB activation and decreased IL-I, IL-6 and TNF-alpha mRNA expression in the kidney tissue. Studies in rodents show that addition of n-3 FA and soy protein to diet affords protection against bone loss induced by ovariectomy in mice due to NF-kappaB expression and decreased activation of osteoclasts. Together, the availale evidence show that increased daily intake of dietary n-3 FA decreases the severity of autoimmune disorders, lessens the chance of developing CVD, and protects against bone loss during post-menopause.
AB - Decreased consumption of n-3 fatty acids (FA) and diets rich in animal proteins, saturated fats and n-6 vegetable oils are associated with a higher incidence of cardiovascular disease (CVD), certain malignancies and autoimmune disorders such as rheumatoid arthritis and Systemic Lupus Erythromatous (SLE), and renal disease. Recent studies show that reduced calorie intake and supplementation of diet with n-3 FA delays the onset of autoimmune renal disease, primarily, due to increased antioxidant enzyme activities, decreased NF-kappaB activation and decreased IL-I, IL-6 and TNF-alpha mRNA expression in the kidney tissue. Studies in rodents show that addition of n-3 FA and soy protein to diet affords protection against bone loss induced by ovariectomy in mice due to NF-kappaB expression and decreased activation of osteoclasts. Together, the availale evidence show that increased daily intake of dietary n-3 FA decreases the severity of autoimmune disorders, lessens the chance of developing CVD, and protects against bone loss during post-menopause.
KW - Autoimmunity
KW - N-3 fatty acids
KW - Osteoporosis
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=42649093525&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42649093525&partnerID=8YFLogxK
U2 - 10.2741/2989
DO - 10.2741/2989
M3 - Article
C2 - 18508495
AN - SCOPUS:42649093525
VL - 13
SP - 4015
EP - 4020
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
SN - 1093-9946
IS - 11
ER -