Effects of methylglyoxal on central and peripheral cholinergic responses

M. G. Davies, P. L. Chambers, M. J. Rowan

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Methylglyoxal (MG) has been shown to have a depolarizing effect on the giant interneurones of the isolated 6th abdominal ganglion of the cockroach. This effect of MG was inhibited by concentrations of nicotine, d-tubocurarine and physostigmine which blocked transmission at the cholinergic cercal nerve-giant interneurone synapse. MG (5 x 10-5 to 5 x 10-4 M) produced concentration-dependent contractures of the isolated frog rectus abdominis muscle which were inhibited by d-tubocurarine (10-4 M) and phystostigmine (10-6 M). MG enhanced the action of acetylcholine and inhibited KCl-evoked contractures whereas it had no effect on the response to carbachol. It is concluded that MG appears to act as a cholinomimetic in both the peripheral and central nervous system.

Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalArchives of Toxicology
Volume59
Issue numberSUPPL. 9
StatePublished - Jan 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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