Effects of mannitol and dextran on interstitial pulmonary edema

Michael E. Reif, James R. McCurdy, Jacqueline J. Coalson, Lazar J. Greenfield

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pulmonary interstitial edema in the isogravimetric perfused canine lung produced by venous constriction results in decreased compliance and pulmonary venous PO2, and increased pulmonary capillary pressure. Release of venous constriction is associated with further deterioration in pulmonary venous PO2, and no improvement in lung weight or compliance although PCi returns toward normal. Addition of 15 grams LMW dextran minimizes the fall in PVO2 and shows less perivascular edema microscopically, but does not otherwise differ from untreated controls. In contrast, deleterious effects are noted after the addition of 1.5 grams mannitol shown by marked weight gain, increased PCi, decreased PVO2, and decreased compliance. In addition, electron microscopy shows focal endothelial cell damage and more marked perivascular space edema. The adverse effects of mannitol may relate to its smaller molecular weight facilitating entry into the interstitial space.

Original languageEnglish (US)
Pages (from-to)234-239
Number of pages6
JournalJournal of Surgical Research
Volume12
Issue number4
DOIs
StatePublished - 1972
Externally publishedYes

Fingerprint

Mannitol
Pulmonary Edema
Dextrans
Lung
Compliance
Constriction
Edema
Weight Gain
Canidae
Electron Microscopy
Endothelial Cells
Molecular Weight
Pressure
Weights and Measures

ASJC Scopus subject areas

  • Surgery

Cite this

Reif, M. E., McCurdy, J. R., Coalson, J. J., & Greenfield, L. J. (1972). Effects of mannitol and dextran on interstitial pulmonary edema. Journal of Surgical Research, 12(4), 234-239. https://doi.org/10.1016/0022-4804(72)90017-0

Effects of mannitol and dextran on interstitial pulmonary edema. / Reif, Michael E.; McCurdy, James R.; Coalson, Jacqueline J.; Greenfield, Lazar J.

In: Journal of Surgical Research, Vol. 12, No. 4, 1972, p. 234-239.

Research output: Contribution to journalArticle

Reif, ME, McCurdy, JR, Coalson, JJ & Greenfield, LJ 1972, 'Effects of mannitol and dextran on interstitial pulmonary edema', Journal of Surgical Research, vol. 12, no. 4, pp. 234-239. https://doi.org/10.1016/0022-4804(72)90017-0
Reif, Michael E. ; McCurdy, James R. ; Coalson, Jacqueline J. ; Greenfield, Lazar J. / Effects of mannitol and dextran on interstitial pulmonary edema. In: Journal of Surgical Research. 1972 ; Vol. 12, No. 4. pp. 234-239.
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