TY - JOUR
T1 - Effects of long-term hemofiltration on circulating mediators and superoxide production during continuous endotoxin administration
AU - Ishihara, Satoshi
AU - Ward, John A.
AU - Tasaki, Osamu
AU - Brinkley, William W.
AU - Seraile, Leonard G.
AU - Pruitt, Basil A.
AU - Mozingo, David W.
PY - 1999/5/1
Y1 - 1999/5/1
N2 - Background: The purpose of this study was to test whether continuous hemofiltration eliminates cytokines and eicosanoids, or stimulates granulocyte function. Methods: Nineteen pigs were divided into a control group (n = 7), a hemofiltration group (n = 7), and an extracorporeal circuit only group (n = 5). All animals received the same amount of intravenous endotoxin and resuscitation fluid. Zero-balanced hemofiltration was started 30 minutes after initiation of endotoxemia and continued throughout the experiment. Plasma endotoxin, tumor necrosis factor-α, eicosanoids, superoxide production, and other physiologic parameters were measured before challenge and at scheduled intervals thereafter. Results: Eicosanoids were filtered but plasma concentrations were not reduced. Tumor necrosis factor- α was not filtered or adsorbed. There were no significant differences between groups in any measured parameters. Conclusion: Continuous hemofiltration could not efficiently remove tumor necrosis factor-α or eicosanoids. Also, continuous hemofiltration did not stimulate production of the proinflammatory mediators measured, nor improve respiratory distress.
AB - Background: The purpose of this study was to test whether continuous hemofiltration eliminates cytokines and eicosanoids, or stimulates granulocyte function. Methods: Nineteen pigs were divided into a control group (n = 7), a hemofiltration group (n = 7), and an extracorporeal circuit only group (n = 5). All animals received the same amount of intravenous endotoxin and resuscitation fluid. Zero-balanced hemofiltration was started 30 minutes after initiation of endotoxemia and continued throughout the experiment. Plasma endotoxin, tumor necrosis factor-α, eicosanoids, superoxide production, and other physiologic parameters were measured before challenge and at scheduled intervals thereafter. Results: Eicosanoids were filtered but plasma concentrations were not reduced. Tumor necrosis factor- α was not filtered or adsorbed. There were no significant differences between groups in any measured parameters. Conclusion: Continuous hemofiltration could not efficiently remove tumor necrosis factor-α or eicosanoids. Also, continuous hemofiltration did not stimulate production of the proinflammatory mediators measured, nor improve respiratory distress.
KW - Hydrogen peroxide anion
KW - Swine
KW - TNF-α, 6-keto prostaglandin F(1α)
KW - Thromboxane B
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U2 - 10.1097/00005373-199905000-00020
DO - 10.1097/00005373-199905000-00020
M3 - Article
C2 - 10338409
AN - SCOPUS:0032936774
VL - 46
SP - 894
EP - 899
JO - Journal of Trauma and Acute Care Surgery
JF - Journal of Trauma and Acute Care Surgery
SN - 2163-0755
IS - 5
ER -