Effects of latanoprost and timolol-XE on hydrodynamics in the normal eye

William Eric Sponsel, Josepha Mensah, J. W. Kiel, A. Remky, Yolanda Trigo, W. Baca, T. Friberg

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To compare the effects of latanoprost and timolol-XE on ocular pressure and perfusion in healthy adults, with respect to episcleral venous pressure. METHODS: A double-masked, placebo-controlled crossover study of weeklong bedtime treatment with one drop of drug, with placebo contralaterally, followed by a 3-week washout and alternate- drug/contralateral-placebo repeat. Intraocular pressure was measured by applanation and by pneumotonometry, providing pulsatile ocular circulatory estimates. Measurements of episcleral venous pressure were obtained (Friberg method). RESULTS: Twenty subjects participated (five men, 15 women; mean age, 39 years (range, 21 to 55 years); mean baseline intraocular pressure, 13.4 mm Hg). A greater decrease in intraocular pressure was seen among these subjects the morning after initiating treatment with latanoprost (-2.0 mm Hg; P < .0001) than with timolol-XE (-0.9 mm Hg; P = .051) (latanoprost versus timolol ΔP = .008). This ocular hypotensive effect remained significant that evening with latanoprost (-3.2 mm Hg; P < .0001) but not with timolol XE (- 1.0 mm Hg; P = .2). By the morning of day 8, mean intraocular pressure remained 3.2 mm Hg below baseline with latanoprost and 2.3 mm Hg below baseline with timolol-XE (P < .0001 for both drugs). Neither drug altered episcleral venous pressure. Among a subgroup of nine subjects with comparable intraocular pressure reductions with the two drugs, latanoprost treatment was associated with a 16.7% increase in mean pulsatile ocular blood flow (P = .04) through the weeklong treatment interval, consistently higher than during timolol-XE treatment of the same subjects. CONCLUSION: Latanoprost caused an overnight decrease in intraocular pressure in normotensive normal eyes, and both drugs significantly reduced intraocular pressure within 1 week. Intraocular pressure remained higher than episcleral venous pressure throughout treatment with both drugs. Latanoprost was associated with enhanced pulsatile ocular perfusion not seen with timolol-XE treatment. (C) 2000 by Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)151-159
Number of pages9
JournalAmerican Journal of Ophthalmology
Volume130
Issue number2
DOIs
StatePublished - Aug 2000

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latanoprost
Timolol
Hydrodynamics
Intraocular Pressure
Venous Pressure
Pharmaceutical Preparations
Placebos
Therapeutics
Pulsatile Flow
Cross-Over Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Sponsel, W. E., Mensah, J., Kiel, J. W., Remky, A., Trigo, Y., Baca, W., & Friberg, T. (2000). Effects of latanoprost and timolol-XE on hydrodynamics in the normal eye. American Journal of Ophthalmology, 130(2), 151-159. https://doi.org/10.1016/S0002-9394(00)00401-3

Effects of latanoprost and timolol-XE on hydrodynamics in the normal eye. / Sponsel, William Eric; Mensah, Josepha; Kiel, J. W.; Remky, A.; Trigo, Yolanda; Baca, W.; Friberg, T.

In: American Journal of Ophthalmology, Vol. 130, No. 2, 08.2000, p. 151-159.

Research output: Contribution to journalArticle

Sponsel, WE, Mensah, J, Kiel, JW, Remky, A, Trigo, Y, Baca, W & Friberg, T 2000, 'Effects of latanoprost and timolol-XE on hydrodynamics in the normal eye', American Journal of Ophthalmology, vol. 130, no. 2, pp. 151-159. https://doi.org/10.1016/S0002-9394(00)00401-3
Sponsel, William Eric ; Mensah, Josepha ; Kiel, J. W. ; Remky, A. ; Trigo, Yolanda ; Baca, W. ; Friberg, T. / Effects of latanoprost and timolol-XE on hydrodynamics in the normal eye. In: American Journal of Ophthalmology. 2000 ; Vol. 130, No. 2. pp. 151-159.
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abstract = "PURPOSE: To compare the effects of latanoprost and timolol-XE on ocular pressure and perfusion in healthy adults, with respect to episcleral venous pressure. METHODS: A double-masked, placebo-controlled crossover study of weeklong bedtime treatment with one drop of drug, with placebo contralaterally, followed by a 3-week washout and alternate- drug/contralateral-placebo repeat. Intraocular pressure was measured by applanation and by pneumotonometry, providing pulsatile ocular circulatory estimates. Measurements of episcleral venous pressure were obtained (Friberg method). RESULTS: Twenty subjects participated (five men, 15 women; mean age, 39 years (range, 21 to 55 years); mean baseline intraocular pressure, 13.4 mm Hg). A greater decrease in intraocular pressure was seen among these subjects the morning after initiating treatment with latanoprost (-2.0 mm Hg; P < .0001) than with timolol-XE (-0.9 mm Hg; P = .051) (latanoprost versus timolol ΔP = .008). This ocular hypotensive effect remained significant that evening with latanoprost (-3.2 mm Hg; P < .0001) but not with timolol XE (- 1.0 mm Hg; P = .2). By the morning of day 8, mean intraocular pressure remained 3.2 mm Hg below baseline with latanoprost and 2.3 mm Hg below baseline with timolol-XE (P < .0001 for both drugs). Neither drug altered episcleral venous pressure. Among a subgroup of nine subjects with comparable intraocular pressure reductions with the two drugs, latanoprost treatment was associated with a 16.7{\%} increase in mean pulsatile ocular blood flow (P = .04) through the weeklong treatment interval, consistently higher than during timolol-XE treatment of the same subjects. CONCLUSION: Latanoprost caused an overnight decrease in intraocular pressure in normotensive normal eyes, and both drugs significantly reduced intraocular pressure within 1 week. Intraocular pressure remained higher than episcleral venous pressure throughout treatment with both drugs. Latanoprost was associated with enhanced pulsatile ocular perfusion not seen with timolol-XE treatment. (C) 2000 by Elsevier Science Inc.",
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AU - Sponsel, William Eric

AU - Mensah, Josepha

AU - Kiel, J. W.

AU - Remky, A.

AU - Trigo, Yolanda

AU - Baca, W.

AU - Friberg, T.

PY - 2000/8

Y1 - 2000/8

N2 - PURPOSE: To compare the effects of latanoprost and timolol-XE on ocular pressure and perfusion in healthy adults, with respect to episcleral venous pressure. METHODS: A double-masked, placebo-controlled crossover study of weeklong bedtime treatment with one drop of drug, with placebo contralaterally, followed by a 3-week washout and alternate- drug/contralateral-placebo repeat. Intraocular pressure was measured by applanation and by pneumotonometry, providing pulsatile ocular circulatory estimates. Measurements of episcleral venous pressure were obtained (Friberg method). RESULTS: Twenty subjects participated (five men, 15 women; mean age, 39 years (range, 21 to 55 years); mean baseline intraocular pressure, 13.4 mm Hg). A greater decrease in intraocular pressure was seen among these subjects the morning after initiating treatment with latanoprost (-2.0 mm Hg; P < .0001) than with timolol-XE (-0.9 mm Hg; P = .051) (latanoprost versus timolol ΔP = .008). This ocular hypotensive effect remained significant that evening with latanoprost (-3.2 mm Hg; P < .0001) but not with timolol XE (- 1.0 mm Hg; P = .2). By the morning of day 8, mean intraocular pressure remained 3.2 mm Hg below baseline with latanoprost and 2.3 mm Hg below baseline with timolol-XE (P < .0001 for both drugs). Neither drug altered episcleral venous pressure. Among a subgroup of nine subjects with comparable intraocular pressure reductions with the two drugs, latanoprost treatment was associated with a 16.7% increase in mean pulsatile ocular blood flow (P = .04) through the weeklong treatment interval, consistently higher than during timolol-XE treatment of the same subjects. CONCLUSION: Latanoprost caused an overnight decrease in intraocular pressure in normotensive normal eyes, and both drugs significantly reduced intraocular pressure within 1 week. Intraocular pressure remained higher than episcleral venous pressure throughout treatment with both drugs. Latanoprost was associated with enhanced pulsatile ocular perfusion not seen with timolol-XE treatment. (C) 2000 by Elsevier Science Inc.

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