Effects of isradipine on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition

Bankole A. Johnson, John D Roache, Nassima Ait-Daoud, Christopher Wallace, Lynda T. Wells, Yanmei Wang

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Rationale: While the effects of d-amphetamine in increasing performance have been established, there is a paucity of information on the effects of methamphetamine on cognition in drug-naive subjects, and no published information on the effects of intravenous methamphetamine administration in dependent individuals. The dihydropyridine-class calcium channel antagonist, isradipine, has been posited as a putative treatment to prevent methamphetamine-associated hypertensive crisis and its sequelae. Yet, isradipine's effects on cognitive performance in methamphetamine-dependent individuals are not known. Objective: Since individuals whose dependence on methamphetamine is attributable to the need to enhance performance may be loath to take a cognition-impairing medication, even for the treatment of life-threatening hypertensive crisis, it would be important to determine isradipine's effects on performance. Methods: We therefore examined in a blinded, placebo-controlled, crossover design the cognitive effects of low and high doses of intravenous methamphetamine (15 mg and 30 mg, respectively) in both the presence and absence of isradipine. Results: Intravenous d-methamphetamine produced dose-dependent increases in attention, concentration, and psychomotor performance. Isradipine, both with and without methamphetamine, had a modest effect to decrease attention. Conclusion: Our results do not support the further testing of isradipine as a medication for improving the cognitive impairments that have been associated with chronic methamphetamine use.

Original languageEnglish (US)
Pages (from-to)296-302
Number of pages7
JournalPsychopharmacology
Volume178
Issue number2-3
DOIs
StatePublished - Mar 2005

Fingerprint

Isradipine
Motor Skills
Methamphetamine
Cognition
Psychomotor Performance
Dextroamphetamine
Calcium Channel Blockers
Intravenous Administration
Cross-Over Studies
Placebos

Keywords

  • Attention
  • Cognition
  • Cognitive performance
  • Concentration
  • Dopamine
  • Humans
  • Isradipine
  • Methamphetamine
  • Perceptual-motor function

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of isradipine on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition. / Johnson, Bankole A.; Roache, John D; Ait-Daoud, Nassima; Wallace, Christopher; Wells, Lynda T.; Wang, Yanmei.

In: Psychopharmacology, Vol. 178, No. 2-3, 03.2005, p. 296-302.

Research output: Contribution to journalArticle

Johnson, Bankole A. ; Roache, John D ; Ait-Daoud, Nassima ; Wallace, Christopher ; Wells, Lynda T. ; Wang, Yanmei. / Effects of isradipine on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition. In: Psychopharmacology. 2005 ; Vol. 178, No. 2-3. pp. 296-302.
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