Effects of intraosseous transfusion of whole blood on hemolysis and transfusion time in a swine model of hemorrhagic shock: A pilot study

James M. Burgert, John Mozer, Tina Williams, Jerry Gostnell, Brian T. Gegel, Sabine Johnson, Michael Bentley, Arthur Don Johnson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

This prospective, experimental, mixed study determined whether there were differences in intraosseous (IO) and intravenous (IV) whole blood transfusion relative to hemolysis and transfusion time. Swine were assigned to the IV group (n = 6) with an 18-gauge catheter in the auricular vein or the IO group (n = 7) with a 15-gauge IO needle in the proximal humerus. Following baseline specimen collection, 900 mL of blood was collected from each animal. The collected blood was autologously transfused by the IV or IO route using a pressure infusion bag inflated to 300 mm Hg, with immediate posttransfusion specimen collection. Hemolysis was defined by the amount of plasma free hemoglobin. Multivariate analysis of variance revealed no significant differences between groups relative to posttransfusion free hemoglobin or transfusion time (P = .065). The IV group's mean free hemoglobin level was 10.23 ± 10.52 μmol/L; the IO group, 7.2 ± 5.82 μmol/L. The IV group's mean transfusion time was 13.48 ± 4.1 minutes; the IO group, 28.70 ± 19.51 minutes. Intraosseous transfusion does not significantly increase hemolysis or transfusion time compared with IV transfusion. Clinically, it can take up to twice as long to transfuse 900 mL of blood IO compared with IV.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalAANA Journal
Volume82
Issue number3
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • Blood transfusion
  • Hemolysis
  • Hemorrhagic shock
  • Intraosseous infusion
  • Intraosseous transfusion

ASJC Scopus subject areas

  • Medical–Surgical
  • Advanced and Specialized Nursing
  • Anesthesiology and Pain Medicine

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