Effects of intraosseous and intravenous administration of Hextend® on time of administration and hemodynamics in a Swine model

Don Johnson, James Dial, Jake Ard, Timothy Yourk, Ellen Burke, Craig Paine, Brian Gegel, James Burgert

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

INTRODUCTION: The military recommends that a 500 mL bolus of Hextend® be administered via an intravenous (IV) 18-gauge needle or via an intraosseous (IO) needle for patients in hypovolemic shock.

PURPOSES: The purposes of this study were to compare the time of administration of Hextend and the hemodynamics of IV and IO routes in a Class II hemorrhage swine model.

METHODS: This was an experimental study using 27 swine. After 30% of their blood volume was exsanguinated, 500 mL of Hextend was administered IV or IO, but not to the control group. Hemodynamic data were collected every 2 minutes until administration was complete.

RESULTS: Time for administration was not significant (p=.78). No significant differences existed between the IO and IV groups relative to hemodynamics (p>.05), but both were significantly different than the control group (p<.05).

CONCLUSIONS: The IO route is an effective method of administering Hextend.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalJournal of special operations medicine : a peer reviewed journal for SOF medical professionals
Volume14
Issue number1
StatePublished - Mar 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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