TY - JOUR
T1 - Effects of inhibition of thyroid function and of cold on melatonin synthesis and porphyrin content in the harderian glands of male syrian hamsters, Mesocricetus Auratus
AU - Buzzell, Gerald R.
AU - Chen, Zilian
AU - Vaughan, Mary K.
AU - Reiter, Russel J.
PY - 1989
Y1 - 1989
N2 - 1. 1. Indole metabolism and porphyrin content of the Harderian glands of the male Syrian hamster were measured as functions of drug-induced hypothyroidism and exposure to cold conditions. 2. 2. Harderian gland N-acetyltransferase (NAT) activity was reduced from control levels by hypothyroidism induced by methimazole; exposure to cold had no effect on NAT activity. 3. 3. Immunoreactive melatonin in the Harderian glands was unaffected by the state of thyroid secretion. However, immunoreactive melatonin content declined after 180 and 270 min, at 4°C, suggesting that Harderian gland melatonin may be involved in thermoregulation. 4. 4. Porphyrin content of the Harderian glands was not affected by either thyroid secretion or cold.
AB - 1. 1. Indole metabolism and porphyrin content of the Harderian glands of the male Syrian hamster were measured as functions of drug-induced hypothyroidism and exposure to cold conditions. 2. 2. Harderian gland N-acetyltransferase (NAT) activity was reduced from control levels by hypothyroidism induced by methimazole; exposure to cold had no effect on NAT activity. 3. 3. Immunoreactive melatonin in the Harderian glands was unaffected by the state of thyroid secretion. However, immunoreactive melatonin content declined after 180 and 270 min, at 4°C, suggesting that Harderian gland melatonin may be involved in thermoregulation. 4. 4. Porphyrin content of the Harderian glands was not affected by either thyroid secretion or cold.
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U2 - 10.1016/0300-9629(89)90116-3
DO - 10.1016/0300-9629(89)90116-3
M3 - Article
C2 - 2574094
AN - SCOPUS:0024458670
VL - 94
SP - 427
EP - 429
JO - Comparative Biochemistry and Physiology -- Part A: Physiology
JF - Comparative Biochemistry and Physiology -- Part A: Physiology
SN - 0300-9629
IS - 3
ER -