TY - JOUR
T1 - Effects of hydrogen chloride on respiratory response and pulmonary function of the baboon
AU - Kaplan, Harold L.
AU - Anzueto, Antonio
AU - Switzer, Walter G.
AU - Hinderer, Robert K.
PY - 1988/4
Y1 - 1988/4
N2 - The effects of hydrogen chloride (HCI inhalation on respiratory response during exposure and on pulmonary function during the 3 mo following exposure were studied in the baboon. Each of 4 groups of three anesthetized animals was exposed in a headonly mode for 15 min to air or one of three HCI concentrations (500, 5000, or 10, 000ppm). The acute respiratory response consisted of a concentration-related increase in frequency and minute volume, with a marked decrease in blood PaO2at the two highest concentrations. The exposures did not cause significant alterations in any of the pulmonary function parameters measured at 3 d and 3 mo postexposure. Thus, nonhuman primates were able to survive short exposures to high concentrations of HCI without any significant effects on pulmonary function during the 3 mo after exposure. Furthermore, comparison of the response of primates and rodents suggests that the human is much less sensitive to the effects of HCI than the mouse.
AB - The effects of hydrogen chloride (HCI inhalation on respiratory response during exposure and on pulmonary function during the 3 mo following exposure were studied in the baboon. Each of 4 groups of three anesthetized animals was exposed in a headonly mode for 15 min to air or one of three HCI concentrations (500, 5000, or 10, 000ppm). The acute respiratory response consisted of a concentration-related increase in frequency and minute volume, with a marked decrease in blood PaO2at the two highest concentrations. The exposures did not cause significant alterations in any of the pulmonary function parameters measured at 3 d and 3 mo postexposure. Thus, nonhuman primates were able to survive short exposures to high concentrations of HCI without any significant effects on pulmonary function during the 3 mo after exposure. Furthermore, comparison of the response of primates and rodents suggests that the human is much less sensitive to the effects of HCI than the mouse.
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U2 - 10.1080/15287398809531129
DO - 10.1080/15287398809531129
M3 - Article
C2 - 3129573
AN - SCOPUS:0023909422
VL - 23
SP - 473
EP - 493
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
SN - 0098-4108
IS - 4
ER -