Effects of hydrocortisone on the formation of gap junctions and the abnormal growth of cilia within the rat anterior pituitary gland: Possible role of gap junctions on the regulation of cell development

Eisuke Sakuma, Tsuyoshi Soji, Damon C. Herbert

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We investigated the effects of hydrocortisone on the formation of gap junctions in and the growth of cilia on folliculo-stellate cells. The male rats of experimental groups were given daily intraperitoneal injections of 5 mg/kg of hydrocortisone from Day 20 to 60. Five rats were killed at ages 10, 20, 30 and 40 days after initiation of injections, and the pituitary gland was removed from each rat. Then, the specimens were prepared for observation by transmission electron microscopy. A delay in the formation of gap junctions between folliculo-stellate cells was observed in hydrocortisone treated rats compared with control rats on Day 30, 40 and 50. Another finding in the present study was the increase of ciliated follicles on Day 40 and 50 in the hydrocortisone treated groups, simultaneous with the delay in gap junction formation. The results suggest that hydrocortisone has a suppressive effect on the gap junction formation between folliculo-stellate cells, and loss of intercellular communication by way of gap junctions may lead to alteration of morphological development of the cell.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalAnatomical Record
Volume262
Issue number2
DOIs
StatePublished - Feb 1 2001

Keywords

  • Anterior pituitary gland
  • Cilia
  • Folliculo-stellate cells
  • Gap junctions
  • Hydrocortisone
  • Rat

ASJC Scopus subject areas

  • Anatomy
  • Agricultural and Biological Sciences (miscellaneous)

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