Effects of hydralazine and sodium nitroprusside on plasma a catecholamines and heart rate

Min Shung Lin, John L. McNay, Alexander M Shepherd, T. Kent Keeton

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Abstract

Hydralazine and sodium nitroprusside induce different effects on systemic hemodynamics, but their effects on sympathetic neuronal activity have not been compared. Five hypertensive subjects receiving only hydrochlorothiazide were studied during two sessions. During one session, four doses of hydralazine, 0.1 to 0.6 mg/kg, were given intravenously at least 3 days apart, and during the other session, sodium nitroprusside was infused in stepwise doses, 0.05 to 4.8 μg/kg/min for 10 min per dose. Mean arterial pressure (MAP), heart rate (HR), and plasma norepinephrine (NE) and epinephrine concentrations were determined before and after dosing. The following correlated linearly for hydralazine and sodium nitroprusside: ΔHR/ΔMAP, ΔNE/ΔMAP, and ΔHR/ΔNE. Comparison of these relationships, however, indicated significant differences between the sympathetic neuronal and hemodynamic responses to hydralazine and sodium nitroprusside. Increase in HR relative to decrease in MAP was greater for hydralazine then for sodium nitroprusside. There were greater increases in plasma NE concentration relative to falls in MAP with sodium nitroprusside than with hydralazine, but increases in HR relative to increases in plasma NE concentration were smaller for sodium nitroprusside than jor hydralazine. Such responses may reflect differential effects of hydralazine and sodium nitroprusside on the systemic clearance of NE or of the activity of cardiopulmonary baroreceptors.

Original languageEnglish (US)
Pages (from-to)474-480
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume34
Issue number4
StatePublished - Oct 1983

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Hydralazine
Nitroprusside
Catecholamines
Heart Rate
Norepinephrine
Arterial Pressure
Hemodynamics
Pressoreceptors
Hydrochlorothiazide
Epinephrine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Lin, M. S., McNay, J. L., Shepherd, A. M., & Kent Keeton, T. (1983). Effects of hydralazine and sodium nitroprusside on plasma a catecholamines and heart rate. Clinical Pharmacology and Therapeutics, 34(4), 474-480.

Effects of hydralazine and sodium nitroprusside on plasma a catecholamines and heart rate. / Lin, Min Shung; McNay, John L.; Shepherd, Alexander M; Kent Keeton, T.

In: Clinical Pharmacology and Therapeutics, Vol. 34, No. 4, 10.1983, p. 474-480.

Research output: Contribution to journalArticle

Lin, MS, McNay, JL, Shepherd, AM & Kent Keeton, T 1983, 'Effects of hydralazine and sodium nitroprusside on plasma a catecholamines and heart rate', Clinical Pharmacology and Therapeutics, vol. 34, no. 4, pp. 474-480.
Lin, Min Shung ; McNay, John L. ; Shepherd, Alexander M ; Kent Keeton, T. / Effects of hydralazine and sodium nitroprusside on plasma a catecholamines and heart rate. In: Clinical Pharmacology and Therapeutics. 1983 ; Vol. 34, No. 4. pp. 474-480.
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