Effects of high‐dose methamphetamine on monoamine uptake sites in rat brain measured by quantitative autoradiography

David J. Brunswick, Saloua Benmansour, Shanaz M. Tejani‐Butt, Miroslawa Hauptmann

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

The neurotoxicity of methamphetamine to monoaminergic neurons was examined. Neurotoxicity was assessed by quantitative autoradiography using radioligands specific for binding to norepinephrine, dopamine, and serotonin uptake sites. High‐dose administration of methamphetamine led to decreases in binding to uptake sites for the three monoamines. Norepinephrine binding sites were decreased in certain amygdaloid nuclei and in the dorsomedial hypothalamic nucleus. Serotonin binding sites were reduced in widespread brain areas, while dopamine binding sites were reduced in the caudate putamen, olfactory tubercle, and nucleus accumbens. The decreases in binding site density for the three monoamines are limited to terminal field areas; cell body areas are not affected. Our results indicate that methamphetamine is neurotoxic to serotonin, dopamine, and norepinephrine neurons. The neurotoxicity to norepinephrine neurons is in selected brain areas. © Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalSynapse
Volume11
Issue number4
DOIs
StatePublished - Aug 1992

Keywords

  • Dopamine
  • Neurotoxicity
  • Norepinephrine
  • Serotonin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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