Effects of glucocorticoids on osteoclast-activating factor

Mark Strumpf, Mary Ann Kowalski, Gregory R. Mundy

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Glucocorticoids lower the serum calcium in patients with hypercalcemia due to myeloma and related lymphoproliferative disorders. OAF is a potent bone-resorbing lymphokine which is probably responsible for the bone lesions and hypercalcemia which occur in patients with these hematological neoplasms. In this study, we have examined the effects of cortisol on the production of OAF and its biological activity in order to clarify the mechanism of action of glucocorticoids in lowering the serum calcium in these disorders. The effects of OAF-containing media on bone resorption were inhibited by cortisol at concentrations from 10-5M to 10-9M. In contrast, OAF production was not inhibited by cortisol at concentrations less than 10-5M. These data support the hypothesis that glucocorticoids inhibit the effects of OAF in vivo primarily by a direct effect on bone resorption.

Original languageEnglish (US)
Pages (from-to)772-778
Number of pages7
JournalThe Journal of Laboratory and Clinical Medicine
Volume92
Issue number5
StatePublished - Nov 1978
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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