Effects of gestational age and labor on the expression of prostanoid receptor genes in pregnant baboon cervix

Gordon C.S. Smith, Wen X. Wu, Peter W. Nathanielsz

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We sought to determine whether expression of genes encoding prostaglandin receptors varied with advancing gestational age and in association with the onset of spontaneous labor in the cervix of pregnant baboons. We performed cesarean hysterectomy on 14 pregnant baboons, five during spontaneous labor. Expression of genes was quantified by Northern analysis. Clear signals which were similar in estimated size to the human genes were detected by Northern analysis for the genes encoding the EP1, EP2, EP3, EP4, FP, IP and TP receptors. Expression of the gene encoding the prostanoid EP1 receptor increased with advancing gestational age prior to labor (r2 = 0.8, P = 0.007). There was a 4 fold lower level of expression of the EP2 receptor gene among animals in labor compared with animals not in labor (P = 0.006) and approximately 2-fold lower levels of expression of the FP and TP receptor genes (P < 0.0001 and P = 0.0002, respectively). We conclude that variation in the relative expression of prostanoid receptor types and sub-types may have a role in cervical dilatation in primate parturition.

Original languageEnglish (US)
Pages (from-to)153-163
Number of pages11
JournalProstaglandins and Other Lipid Mediators
Volume63
Issue number4
DOIs
StatePublished - Apr 5 2001
Externally publishedYes

Keywords

  • Cervix
  • Genetics
  • Labor
  • Papio species
  • Prostaglandin
  • Receptors

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

Fingerprint Dive into the research topics of 'Effects of gestational age and labor on the expression of prostanoid receptor genes in pregnant baboon cervix'. Together they form a unique fingerprint.

  • Cite this