Effects of focused force angioplasty: Pre-clinical experience and clinical confirmation

David Meerkin, Seung H. Lee, Fermin O. Tio, Erberharde Grube, S. Chiu Wong, Mun K. Hong

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Balloon angioplasty results in a combination of plaque compression and fracture, creation of intimal flaps and localized medial dissection, as well as the stretching and remodeling of the arterial wall. The application of eccentric pressure to the vessel wall allows for the balloon force to be focused along a specified line resulting in a reduction in vessel resistance with an improved or equivalent result at a lower pressure. The FX miniRAIL is a novel balloon angioplasty catheter that has two external wires that are compressed by the inflating balloon into the vessel wall. It was tested in comparison to conventional balloon injury in a porcine coronary model. At equivalent balloon artery ratios no increase in the length of dissections occured, but a characteristic longitudinal "cut" was noted in the presence of the FX miniRAIL. A similar finding was demonstrated in sample human cases when interrogated by IVUS and OCT.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalJournal of Invasive Cardiology
Issue number4
StatePublished - Apr 2005
Externally publishedYes


  • Balloon angioplasty
  • Controlled dissection
  • Coronary artery disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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