Effects of exercise on aortic input impedance and pressure wave forms in normal humans

Joseph P Murgo, N. Westerhof, J. P. Giolma, S. A. Altobelli

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The effects of supine bicycle exercise on the input impedance of the ascending aorta were studied in thirteen male subjects undergoing cardiac catheterization, but in whom no cardiovascular disease was found. Ascending aortic flow velocity and pressure were recorded simultaneously from a multisensor catheter with an electromagnetic flow velocity probe and a pressure sensor mounted at the same location. A second pressure sensor at the catheter tip provided left ventricular pressure. Fick cardiac outputs were used to scale the velocity signal to instantaneous volumetric flow. Input impedance was calculated from 10 harmonics of aortic pressure and flow. For each subject, impedance moduli and phases from a minimum of 15 beats during rest and exercise were averaged. Peripheral resistance decreased from a resting value of 1142 ± (± SE) dynes sec/cm5 to 712 ± 39 dynes sec/cm5 during exercise. Characteristic impedance remained unchanged with a resting value of 47 ± 4 dynes sec/cm5 and an exercise value of 45 ± 4 dynes sec/cm5. These results were associated with an increase in aortic pressure (96 ± 2 to 111 ± 2 mm Hg) and pulse wave velocity implying a decrease in aortic compliance. An increase in aortic cross-sectional area apparently offsets the effects of these changes in compliance and pulse wave velocity to result in an unchanged characteristic impedance. The increase in pulse wave velocity caused wave reflections to occur earlier during exercise, but the general characteristics of the pressure wave shapes remained unchanged.

Original languageEnglish (US)
Pages (from-to)334-343
Number of pages10
JournalCirculation Research
Volume48
Issue number3
StatePublished - 1981

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Electric Impedance
Pulse Wave Analysis
Pressure
Compliance
Arterial Pressure
Catheters
Electromagnetic Phenomena
Ventricular Pressure
Cardiac Catheterization
Cardiac Output
Vascular Resistance
Aorta
Cardiovascular Diseases

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Murgo, J. P., Westerhof, N., Giolma, J. P., & Altobelli, S. A. (1981). Effects of exercise on aortic input impedance and pressure wave forms in normal humans. Circulation Research, 48(3), 334-343.

Effects of exercise on aortic input impedance and pressure wave forms in normal humans. / Murgo, Joseph P; Westerhof, N.; Giolma, J. P.; Altobelli, S. A.

In: Circulation Research, Vol. 48, No. 3, 1981, p. 334-343.

Research output: Contribution to journalArticle

Murgo, JP, Westerhof, N, Giolma, JP & Altobelli, SA 1981, 'Effects of exercise on aortic input impedance and pressure wave forms in normal humans', Circulation Research, vol. 48, no. 3, pp. 334-343.
Murgo JP, Westerhof N, Giolma JP, Altobelli SA. Effects of exercise on aortic input impedance and pressure wave forms in normal humans. Circulation Research. 1981;48(3):334-343.
Murgo, Joseph P ; Westerhof, N. ; Giolma, J. P. ; Altobelli, S. A. / Effects of exercise on aortic input impedance and pressure wave forms in normal humans. In: Circulation Research. 1981 ; Vol. 48, No. 3. pp. 334-343.
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