Effects of ethanol withdrawal on ethanol-reinforced responding in rhesus monkeys

Gail Winger

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Rhesus monkeys self-administered ethanol intravenously during daily, 3-h sessions. When ethanol-reinforced responding was stable and ethanol intake was in the range of 2.6-3.6 g/kg/3 h, physiological dependence to ethanol was induced by daily passive infusions of additional ethanol. In less than 1 week, mild to moderate withdrawal signs were observed prior to daily sessions. Ethanol intake was suppressed in the presence of these withdrawal signs and returned to normal only after withdrawal signs had subsided.

Original languageEnglish (US)
Pages (from-to)235-240
Number of pages6
JournalDrug and Alcohol Dependence
Issue number3
StatePublished - Dec 1988
Externally publishedYes


  • ethanol-reinforced responding
  • physiological dependence
  • rhesus monkeys

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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