Effects of ethanol on acetylcholine and GABA release: differences in the role of potassium.

R. Strong; C. Rehwaldt; W. G. Wood; A. Y. Sun; G. Y. Sun

Effects of ethanol on acetylcholine and GABA release: differences in the role of potassium.

R. Strong, C. Rehwaldt, W. G. Wood, A. Y. Sun, G. Y. Sun

Research output: Contribution to journal › Article › peer-review

Abstract

Ethanol inhibited electrically stimulated [3H]ACh release from cortical brain slices, but not when release was stimulated by high potassium. In contrast, ethanol was ineffective on electrically stimulated release of [14]GABA from cortical brain slices, but inhibited potassium-induced release. Ethanol also significantly inhibited potassium-stimulated [14C]GABA release from cortical synaptosomes. These data suggest that ethanol selectively inhibits GABA release from neurons by a specific effect on potassium conductance, and inhibits ACh release by a selective effect on Na+ conductance.

Original language	English (US)
Pages (from-to)	631-635
Number of pages	5
Journal	Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.
Volume	1
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Effects of ethanol on acetylcholine and GABA release: differences in the role of potassium.",

abstract = "Ethanol inhibited electrically stimulated [3H]ACh release from cortical brain slices, but not when release was stimulated by high potassium. In contrast, ethanol was ineffective on electrically stimulated release of [14]GABA from cortical brain slices, but inhibited potassium-induced release. Ethanol also significantly inhibited potassium-stimulated [14C]GABA release from cortical synaptosomes. These data suggest that ethanol selectively inhibits GABA release from neurons by a specific effect on potassium conductance, and inhibits ACh release by a selective effect on Na+ conductance.",

author = "R. Strong and C. Rehwaldt and Wood, \{W. G.\} and Sun, \{A. Y.\} and Sun, \{G. Y.\}",

year = "1987",

language = "English (US)",

volume = "1",

pages = "631--635",

journal = "Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.",

issn = "1358-6173",

publisher = "Oxford University Press",

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T1 - Effects of ethanol on acetylcholine and GABA release

T2 - differences in the role of potassium.

AU - Strong, R.

AU - Rehwaldt, C.

AU - Wood, W. G.

AU - Sun, A. Y.

AU - Sun, G. Y.

PY - 1987

Y1 - 1987

N2 - Ethanol inhibited electrically stimulated [3H]ACh release from cortical brain slices, but not when release was stimulated by high potassium. In contrast, ethanol was ineffective on electrically stimulated release of [14]GABA from cortical brain slices, but inhibited potassium-induced release. Ethanol also significantly inhibited potassium-stimulated [14C]GABA release from cortical synaptosomes. These data suggest that ethanol selectively inhibits GABA release from neurons by a specific effect on potassium conductance, and inhibits ACh release by a selective effect on Na+ conductance.

AB - Ethanol inhibited electrically stimulated [3H]ACh release from cortical brain slices, but not when release was stimulated by high potassium. In contrast, ethanol was ineffective on electrically stimulated release of [14]GABA from cortical brain slices, but inhibited potassium-induced release. Ethanol also significantly inhibited potassium-stimulated [14C]GABA release from cortical synaptosomes. These data suggest that ethanol selectively inhibits GABA release from neurons by a specific effect on potassium conductance, and inhibits ACh release by a selective effect on Na+ conductance.

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M3 - Article

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AN - SCOPUS:0023461636

SN - 1358-6173

VL - 1

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EP - 635

JO - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.

JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.

ER -

Effects of ethanol on acetylcholine and GABA release: differences in the role of potassium.

Abstract

ASJC Scopus subject areas

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