Effects of either forskolin, the 1,9-dideoxy derivative of forskolin, or 8-bromocyclic AMP on cyclic AMP and melatonin production in the Syrian hamster pineal gland in organ culture

Celsa Santana; Juan M. Guerrero; Russel J. Reiter

doi:10.1016/0304-3940(89)90123-7

Effects of either forskolin, the 1,9-dideoxy derivative of forskolin, or 8-bromocyclic AMP on cyclic AMP and melatonin production in the Syrian hamster pineal gland in organ culture

Celsa Santana, Juan M. Guerrero, Russel J. Reiter

Department of Cell Systems & Anatomy

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9 Scopus citations

Abstract

The possible involvement of cyclic AMP in the regulation of melatonin production was investigated in cultured Syrian hamster pineal glands. Addition of forskolin, an adenylate cyclase activator, to the incubation medium caused marked increases in both cyclic AMP and melatonin levels in glands collected in the second half of the dark period 8-Bromocyclic AMP, an analogue of cyclic AMP, also increased melatonin production. The 1,9-dideoxy derivative of forskolin, which is unable to activate the cyclase, was ineffective in stimulating either cyclic AMP levels or melatonin production. These results support a primary role for cyclic AMP in the nocturnal increase of melatonin production in the Syrian hamster pineal gland.

Original language	English (US)
Pages (from-to)	338-342
Number of pages	5
Journal	Neuroscience Letters
Volume	103
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(89)90123-7
State	Published - Sep 11 1989

Keywords

Cyclic adenosine monophosphate
Melatonin
Organ culture
Pineal gland
Syrian hamster

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(89)90123-7

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Effects of either forskolin, the 1,9-dideoxy derivative of forskolin, or 8-bromocyclic AMP on cyclic AMP and melatonin production in the Syrian hamster pineal gland in organ culture. / Santana, Celsa; Guerrero, Juan M.; Reiter, Russel J.
In: Neuroscience Letters, Vol. 103, No. 3, 11.09.1989, p. 338-342.

Research output: Contribution to journal › Article › peer-review

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title = "Effects of either forskolin, the 1,9-dideoxy derivative of forskolin, or 8-bromocyclic AMP on cyclic AMP and melatonin production in the Syrian hamster pineal gland in organ culture",

abstract = "The possible involvement of cyclic AMP in the regulation of melatonin production was investigated in cultured Syrian hamster pineal glands. Addition of forskolin, an adenylate cyclase activator, to the incubation medium caused marked increases in both cyclic AMP and melatonin levels in glands collected in the second half of the dark period 8-Bromocyclic AMP, an analogue of cyclic AMP, also increased melatonin production. The 1,9-dideoxy derivative of forskolin, which is unable to activate the cyclase, was ineffective in stimulating either cyclic AMP levels or melatonin production. These results support a primary role for cyclic AMP in the nocturnal increase of melatonin production in the Syrian hamster pineal gland.",

keywords = "Cyclic adenosine monophosphate, Melatonin, Organ culture, Pineal gland, Syrian hamster",

author = "Celsa Santana and Guerrero, {Juan M.} and Reiter, {Russel J.}",

note = "Funding Information: This work was supported by NSF Grant DCB 8410592; C.S. was supported by a postdoctoral fellowship from the Canarias Autonomous Government and Caja de Ahorros de Canarias; J.M.G. was supported by a postdoctoral fellowship from the Fulbright Commission.",

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AU - Santana, Celsa

AU - Guerrero, Juan M.

AU - Reiter, Russel J.

N1 - Funding Information: This work was supported by NSF Grant DCB 8410592; C.S. was supported by a postdoctoral fellowship from the Canarias Autonomous Government and Caja de Ahorros de Canarias; J.M.G. was supported by a postdoctoral fellowship from the Fulbright Commission.

PY - 1989/9/11

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N2 - The possible involvement of cyclic AMP in the regulation of melatonin production was investigated in cultured Syrian hamster pineal glands. Addition of forskolin, an adenylate cyclase activator, to the incubation medium caused marked increases in both cyclic AMP and melatonin levels in glands collected in the second half of the dark period 8-Bromocyclic AMP, an analogue of cyclic AMP, also increased melatonin production. The 1,9-dideoxy derivative of forskolin, which is unable to activate the cyclase, was ineffective in stimulating either cyclic AMP levels or melatonin production. These results support a primary role for cyclic AMP in the nocturnal increase of melatonin production in the Syrian hamster pineal gland.

AB - The possible involvement of cyclic AMP in the regulation of melatonin production was investigated in cultured Syrian hamster pineal glands. Addition of forskolin, an adenylate cyclase activator, to the incubation medium caused marked increases in both cyclic AMP and melatonin levels in glands collected in the second half of the dark period 8-Bromocyclic AMP, an analogue of cyclic AMP, also increased melatonin production. The 1,9-dideoxy derivative of forskolin, which is unable to activate the cyclase, was ineffective in stimulating either cyclic AMP levels or melatonin production. These results support a primary role for cyclic AMP in the nocturnal increase of melatonin production in the Syrian hamster pineal gland.

KW - Cyclic adenosine monophosphate

KW - Melatonin

KW - Organ culture

KW - Pineal gland

KW - Syrian hamster

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ER -

Effects of either forskolin, the 1,9-dideoxy derivative of forskolin, or 8-bromocyclic AMP on cyclic AMP and melatonin production in the Syrian hamster pineal gland in organ culture

Abstract

Keywords

ASJC Scopus subject areas

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