Effects of dopamine antagonists in a two-way active avoidance procedure in rats: Interactions with 8-OH-DPAT, ritanserin, and prazosin

E. P.M. Prinssen, Mark S. Kleven, Wouter Koek

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT(1A) agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhibitory effects of both raclopride and haloperidol on the conditioned avoidance response and produced a small enhancement of the effects of haloperidol on escape failures. The α1-adrenoceptor antagonist prazosin (0.63 mg/kg) significantly enhanced the effects of raclopride on the conditioned avoidance response, but enhanced the effects of only a single dose of haloperidol; prazosin did not alter the effects of either dopamine antagonist on escape failures. The 5-HT2 antagonist ritanserin (0.16 mg/kg) failed significantly to alter the effects of the dopamine antagonists examined here. These findings suggest that blockade of 5-HT2 receptors may not enhance the antipsychotic efficacy of D2-like antagonists. Further, they confirm previous findings with respect to interactions between 5-HT(1A) agonists and neuroleptics, and support the hypothesis that combined 5-HT(1A) agonist/D2-like antagonist properties may be of clinical importance.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalPsychopharmacology
Volume128
Issue number2
DOIs
StatePublished - Nov 26 1996
Externally publishedYes

Keywords

  • conditioned avoidance response
  • dopamine D receptor
  • neuroleptics
  • rats
  • schizophrenia
  • serotonin 5-HT receptor
  • α-adrenoceptor

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Effects of dopamine antagonists in a two-way active avoidance procedure in rats: Interactions with 8-OH-DPAT, ritanserin, and prazosin'. Together they form a unique fingerprint.

Cite this