Abstract
Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT(1A) agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhibitory effects of both raclopride and haloperidol on the conditioned avoidance response and produced a small enhancement of the effects of haloperidol on escape failures. The α1-adrenoceptor antagonist prazosin (0.63 mg/kg) significantly enhanced the effects of raclopride on the conditioned avoidance response, but enhanced the effects of only a single dose of haloperidol; prazosin did not alter the effects of either dopamine antagonist on escape failures. The 5-HT2 antagonist ritanserin (0.16 mg/kg) failed significantly to alter the effects of the dopamine antagonists examined here. These findings suggest that blockade of 5-HT2 receptors may not enhance the antipsychotic efficacy of D2-like antagonists. Further, they confirm previous findings with respect to interactions between 5-HT(1A) agonists and neuroleptics, and support the hypothesis that combined 5-HT(1A) agonist/D2-like antagonist properties may be of clinical importance.
Original language | English (US) |
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Pages (from-to) | 191-197 |
Number of pages | 7 |
Journal | Psychopharmacology |
Volume | 128 |
Issue number | 2 |
DOIs | |
State | Published - Nov 26 1996 |
Externally published | Yes |
Keywords
- conditioned avoidance response
- dopamine D receptor
- neuroleptics
- rats
- schizophrenia
- serotonin 5-HT receptor
- α-adrenoceptor
ASJC Scopus subject areas
- Pharmacology