Abstract
Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT(1A) agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhibitory effects of both raclopride and haloperidol on the conditioned avoidance response and produced a small enhancement of the effects of haloperidol on escape failures. The α1-adrenoceptor antagonist prazosin (0.63 mg/kg) significantly enhanced the effects of raclopride on the conditioned avoidance response, but enhanced the effects of only a single dose of haloperidol; prazosin did not alter the effects of either dopamine antagonist on escape failures. The 5-HT2 antagonist ritanserin (0.16 mg/kg) failed significantly to alter the effects of the dopamine antagonists examined here. These findings suggest that blockade of 5-HT2 receptors may not enhance the antipsychotic efficacy of D2-like antagonists. Further, they confirm previous findings with respect to interactions between 5-HT(1A) agonists and neuroleptics, and support the hypothesis that combined 5-HT(1A) agonist/D2-like antagonist properties may be of clinical importance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 191-197 |
| Number of pages | 7 |
| Journal | Psychopharmacology |
| Volume | 128 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1996 |
| Externally published | Yes |
Fingerprint
Keywords
- α-adrenoceptor
- conditioned avoidance response
- dopamine D receptor
- neuroleptics
- rats
- schizophrenia
- serotonin 5-HT receptor
ASJC Scopus subject areas
- Pharmacology
Cite this
Effects of dopamine antagonists in a two-way active avoidance procedure in rats : Interactions with 8-OH-DPAT, ritanserin, and prazosin. / Prinssen, E. P M; Kleven, Mark S.; Koek, Wouter.
In: Psychopharmacology, Vol. 128, No. 2, 1996, p. 191-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of dopamine antagonists in a two-way active avoidance procedure in rats
T2 - Interactions with 8-OH-DPAT, ritanserin, and prazosin
AU - Prinssen, E. P M
AU - Kleven, Mark S.
AU - Koek, Wouter
PY - 1996
Y1 - 1996
N2 - Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT(1A) agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhibitory effects of both raclopride and haloperidol on the conditioned avoidance response and produced a small enhancement of the effects of haloperidol on escape failures. The α1-adrenoceptor antagonist prazosin (0.63 mg/kg) significantly enhanced the effects of raclopride on the conditioned avoidance response, but enhanced the effects of only a single dose of haloperidol; prazosin did not alter the effects of either dopamine antagonist on escape failures. The 5-HT2 antagonist ritanserin (0.16 mg/kg) failed significantly to alter the effects of the dopamine antagonists examined here. These findings suggest that blockade of 5-HT2 receptors may not enhance the antipsychotic efficacy of D2-like antagonists. Further, they confirm previous findings with respect to interactions between 5-HT(1A) agonists and neuroleptics, and support the hypothesis that combined 5-HT(1A) agonist/D2-like antagonist properties may be of clinical importance.
AB - Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT(1A) agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhibitory effects of both raclopride and haloperidol on the conditioned avoidance response and produced a small enhancement of the effects of haloperidol on escape failures. The α1-adrenoceptor antagonist prazosin (0.63 mg/kg) significantly enhanced the effects of raclopride on the conditioned avoidance response, but enhanced the effects of only a single dose of haloperidol; prazosin did not alter the effects of either dopamine antagonist on escape failures. The 5-HT2 antagonist ritanserin (0.16 mg/kg) failed significantly to alter the effects of the dopamine antagonists examined here. These findings suggest that blockade of 5-HT2 receptors may not enhance the antipsychotic efficacy of D2-like antagonists. Further, they confirm previous findings with respect to interactions between 5-HT(1A) agonists and neuroleptics, and support the hypothesis that combined 5-HT(1A) agonist/D2-like antagonist properties may be of clinical importance.
KW - α-adrenoceptor
KW - conditioned avoidance response
KW - dopamine D receptor
KW - neuroleptics
KW - rats
KW - schizophrenia
KW - serotonin 5-HT receptor
UR - http://www.scopus.com/inward/record.url?scp=0029822710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029822710&partnerID=8YFLogxK
U2 - 10.1007/s002130050124
DO - 10.1007/s002130050124
M3 - Article
C2 - 8956380
AN - SCOPUS:0029822710
VL - 128
SP - 191
EP - 197
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 2
ER -