Effects of cyclic compressive loading on a biodegradable implant

D. Thompson, C. M. Agrawal, K. Athanasiou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mechanical stresses change the mechanical behavior and drug release kinetics of implants. The biodegradable implants made of 50:50 PLA/PGA were subjected to dynamic compressive loading. The implants underwent a volume reduction and became significantly stiffer compared to the unloaded specimens, because the external stresses made the pores in the polymer matrix collapse. The collapse also left a smaller surface area for hydrolysis, thus reducing the rate of molecular degradation.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
Place of PublicationSt. Louis Park, MN, United States
PublisherSoc for Biomaterials
Pages877
Number of pages1
Volume1
StatePublished - 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

Fingerprint

Prostaglandins A
Polymer matrix
Hydrolysis
Degradation
Kinetics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Thompson, D., Agrawal, C. M., & Athanasiou, K. (1996). Effects of cyclic compressive loading on a biodegradable implant. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 1, pp. 877). St. Louis Park, MN, United States: Soc for Biomaterials.

Effects of cyclic compressive loading on a biodegradable implant. / Thompson, D.; Agrawal, C. M.; Athanasiou, K.

Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. ed. / Anon. Vol. 1 St. Louis Park, MN, United States : Soc for Biomaterials, 1996. p. 877.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Thompson, D, Agrawal, CM & Athanasiou, K 1996, Effects of cyclic compressive loading on a biodegradable implant. in Anon (ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 1, Soc for Biomaterials, St. Louis Park, MN, United States, pp. 877, Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, 5/29/96.
Thompson D, Agrawal CM, Athanasiou K. Effects of cyclic compressive loading on a biodegradable implant. In Anon, editor, Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. Vol. 1. St. Louis Park, MN, United States: Soc for Biomaterials. 1996. p. 877
Thompson, D. ; Agrawal, C. M. ; Athanasiou, K. / Effects of cyclic compressive loading on a biodegradable implant. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. editor / Anon. Vol. 1 St. Louis Park, MN, United States : Soc for Biomaterials, 1996. pp. 877
@inproceedings{2ab0641e381543b7b16d056666f269ab,
title = "Effects of cyclic compressive loading on a biodegradable implant",
abstract = "Mechanical stresses change the mechanical behavior and drug release kinetics of implants. The biodegradable implants made of 50:50 PLA/PGA were subjected to dynamic compressive loading. The implants underwent a volume reduction and became significantly stiffer compared to the unloaded specimens, because the external stresses made the pores in the polymer matrix collapse. The collapse also left a smaller surface area for hydrolysis, thus reducing the rate of molecular degradation.",
author = "D. Thompson and Agrawal, {C. M.} and K. Athanasiou",
year = "1996",
language = "English (US)",
volume = "1",
pages = "877",
editor = "Anon",
booktitle = "Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium",
publisher = "Soc for Biomaterials",

}

TY - GEN

T1 - Effects of cyclic compressive loading on a biodegradable implant

AU - Thompson, D.

AU - Agrawal, C. M.

AU - Athanasiou, K.

PY - 1996

Y1 - 1996

N2 - Mechanical stresses change the mechanical behavior and drug release kinetics of implants. The biodegradable implants made of 50:50 PLA/PGA were subjected to dynamic compressive loading. The implants underwent a volume reduction and became significantly stiffer compared to the unloaded specimens, because the external stresses made the pores in the polymer matrix collapse. The collapse also left a smaller surface area for hydrolysis, thus reducing the rate of molecular degradation.

AB - Mechanical stresses change the mechanical behavior and drug release kinetics of implants. The biodegradable implants made of 50:50 PLA/PGA were subjected to dynamic compressive loading. The implants underwent a volume reduction and became significantly stiffer compared to the unloaded specimens, because the external stresses made the pores in the polymer matrix collapse. The collapse also left a smaller surface area for hydrolysis, thus reducing the rate of molecular degradation.

UR - http://www.scopus.com/inward/record.url?scp=0030398398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030398398&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0030398398

VL - 1

SP - 877

BT - Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium

A2 - Anon, null

PB - Soc for Biomaterials

CY - St. Louis Park, MN, United States

ER -