Effects of cyclic compressive loading on a biodegradable implant

D. Thompson, C. M. Agrawal, K. Athanasiou

Research output: Contribution to conferencePaperpeer-review

Abstract

Mechanical stresses change the mechanical behavior and drug release kinetics of implants. The biodegradable implants made of 50:50 PLA/PGA were subjected to dynamic compressive loading. The implants underwent a volume reduction and became significantly stiffer compared to the unloaded specimens, because the external stresses made the pores in the polymer matrix collapse. The collapse also left a smaller surface area for hydrolysis, thus reducing the rate of molecular degradation.

Original languageEnglish (US)
Number of pages1
StatePublished - 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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