Effects of cyclic compressive loading on a biodegradable implant

D. Thompson; C. M. Agrawal; K. Athanasiou

Effects of cyclic compressive loading on a biodegradable implant

D. Thompson, C. M. Agrawal, K. Athanasiou

Department of Orthopaedics

Research output: Contribution to conference › Paper › peer-review

Abstract

Mechanical stresses change the mechanical behavior and drug release kinetics of implants. The biodegradable implants made of 50:50 PLA/PGA were subjected to dynamic compressive loading. The implants underwent a volume reduction and became significantly stiffer compared to the unloaded specimens, because the external stresses made the pores in the polymer matrix collapse. The collapse also left a smaller surface area for hydrolysis, thus reducing the rate of molecular degradation.

Original language	English (US)
Number of pages	1
State	Published - 1996
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

Other

Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

ASJC Scopus subject areas

Materials Science(all)

Cite this

@conference{2ab0641e381543b7b16d056666f269ab,

title = "Effects of cyclic compressive loading on a biodegradable implant",

abstract = "Mechanical stresses change the mechanical behavior and drug release kinetics of implants. The biodegradable implants made of 50:50 PLA/PGA were subjected to dynamic compressive loading. The implants underwent a volume reduction and became significantly stiffer compared to the unloaded specimens, because the external stresses made the pores in the polymer matrix collapse. The collapse also left a smaller surface area for hydrolysis, thus reducing the rate of molecular degradation.",

author = "D. Thompson and Agrawal, {C. M.} and K. Athanasiou",

year = "1996",

language = "English (US)",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

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TY - CONF

T1 - Effects of cyclic compressive loading on a biodegradable implant

AU - Thompson, D.

AU - Agrawal, C. M.

AU - Athanasiou, K.

PY - 1996

Y1 - 1996

N2 - Mechanical stresses change the mechanical behavior and drug release kinetics of implants. The biodegradable implants made of 50:50 PLA/PGA were subjected to dynamic compressive loading. The implants underwent a volume reduction and became significantly stiffer compared to the unloaded specimens, because the external stresses made the pores in the polymer matrix collapse. The collapse also left a smaller surface area for hydrolysis, thus reducing the rate of molecular degradation.

AB - Mechanical stresses change the mechanical behavior and drug release kinetics of implants. The biodegradable implants made of 50:50 PLA/PGA were subjected to dynamic compressive loading. The implants underwent a volume reduction and became significantly stiffer compared to the unloaded specimens, because the external stresses made the pores in the polymer matrix collapse. The collapse also left a smaller surface area for hydrolysis, thus reducing the rate of molecular degradation.

UR - http://www.scopus.com/inward/record.url?scp=0030398398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030398398&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:0030398398

T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Effects of cyclic compressive loading on a biodegradable implant

Abstract

Other

ASJC Scopus subject areas

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