Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model

Binqiang Tian, Zhiping Wang, Yingmei Zhao, Degui Wang, Yonggang Li, Li Ma, Xiaoming Li, Jing Li, Nan Xiao, Junqiang Tian, Ronald Rodriguez

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Curcumin, a well-known dietary pigment derived from Curcuma longa, inhibited growth of several types of malignant cells both in vivo and in vitro. Its effects on cell proliferation and the induction of apoptosis in human bladder cancer cell lines and intravesical activity in a rat bladder tumor model were studied. Exposure of human bladder cancer cells to curcumin resulted in the induction of apoptotic cell death and caused cells to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein was downregulated by the curcumin treatment together with enhancement of the Bax and p53 expression. The inhibitory activities of curcumin were stronger than those of cisplatin and could not be prevented by catalase pretreatment in T24 cells. Clonal assay indicated large-dose and short-term curcumin was lethal to bladder cancer cells. Moreover, the in vivo study revealed curcumin did induce apoptosis in situ, inhibit and slow the development of bladder cancer. These observations suggest that curcumin could prove an effective chemopreventive and chemotherapy agent for bladder cancer.

Original languageEnglish (US)
Pages (from-to)299-308
Number of pages10
JournalCancer Letters
Volume264
Issue number2
DOIs
StatePublished - Jun 18 2008

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Keywords

  • Apoptosis
  • Bladder
  • Carcinoma
  • Curcumin
  • Inhibition
  • Transitional cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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