Effects of conjugated linoleic acid and metformin on insulin sensitivity in obese children: Randomized clinical trial

Nayely Garibay-Nieto, Gloria Queipo-García, Flor Alvarez, Mayra Bustos, Erendira Villanueva, Fernando Ramírez, Mireya León, Estibalitz Laresgoiti-Servitje, Ravindranath Duggirala, Teresa Macías, Sergio Cuevas, Abel Jalife, Miguel Fonseca-Sánchez, Fabiola Serratos, Juan Carlos López-Alvarenga

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5 Scopus citations

Abstract

Context: Insulin resistance precedes metabolic syndrome abnormalities and may promote cardiovascular disease and type 2 diabetes in children with obesity. Results of lifestyle modification programs have been discouraging, and the use of adjuvant strategies has been necessary. Objective: This study aimed to evaluate the effects of metformin and conjugated linoleic acid (CLA) on insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp technique and insulin pathway expression molecules in muscle biopsies of children with obesity. Design: A randomized, double-blinded, placebo-controlled clinical trial was conducted. Setting: Children with obesity were randomly assigned to receive metformin, CLA, or placebo. Results: Intervention had a positive effect in all groups. For insulin sensitivity Rd value (mg/kg/min), there was a statistically significant difference between the CLA vs placebo (6.5362.54 vs 5.0561.46, P = 0.035). Insulinemia and homeostatic model assessment of insulin resistance significantly improved in the CLA group (P = 0.045). After analysis of covariance was performed and the influence of body mass index, age, Tanner stage, prescribed diet, and fitness achievement was controlled, a clinically relevant effect size on insulin sensitivity remained evident in the CLA group (37%) and exceeded lifestyle program benefits. Moreover, upregulated expression of the insulin receptor substrate 2 was evident in muscle biopsies of the CLA group. Conclusions: Improvement of insulin sensitivity,measured via euglycemic-hyperinsulinemic clamp and IRS2 upregulation, favored patients treated with CLA.

Original languageEnglish (US)
Pages (from-to)132-140
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume102
Issue number1
DOIs
Publication statusPublished - Jan 1 2017
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Garibay-Nieto, N., Queipo-García, G., Alvarez, F., Bustos, M., Villanueva, E., Ramírez, F., ... López-Alvarenga, J. C. (2017). Effects of conjugated linoleic acid and metformin on insulin sensitivity in obese children: Randomized clinical trial. Journal of Clinical Endocrinology and Metabolism, 102(1), 132-140. https://doi.org/10.1210/jc.2016-2701